Assessment of Left Ventricular Myocardial Dysfunction in Children With End-Stage Kidney Disease Using Two-Dimensional and Three-Dimensional Speckle-Tracking Echocardiography

NCT07678710 | Completed

• 1 other identifier: 293
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The present study aimed to assess left ventricular myocardial dysfunction in children with chronic kidney disease using 2D and 3D speckle-tracking echocardiography.

Conditions

Left Ventricular Myocardial Dysfunction; End-Stage Kidney Disease; Two-Dimensional Speckle-Tracking Echocardiography; Three-Dimensional Speckle-Tracking Echocardiography; Children

Outcome Measures

Primary Outcomes (1)

• Left ventricular systolic function

  Left ventricular systolic function was evaluated by calculating the left ventricular ejection fraction (LVEF) using the biplane Simpson's method from apical four- and two-chamber views.

  At baseline

Study Arms (1)

Study group

Children with end-stage chronic kidney disease (CKD) on regular maintenance hemodialysis.

Device: Two-Dimensional Speckle-Tracking Echocardiography (2D-STE); Device: Three-Dimensional Speckle-Tracking Echocardiography (3D-STE)

Interventions

Two-Dimensional Speckle-Tracking Echocardiography (2D-STE) DEVICE

2D speckle-tracking echocardiography was used to assess left ventricular myocardial deformation. Standard apical four-, two-, and three-chamber views were acquired with optimized frame rates.

Study group

Three-Dimensional Speckle-Tracking Echocardiography (3D-STE) DEVICE

Three-dimensional datasets were acquired from apical full-volume images, ensuring optimal electrocardiographic gating, adequate frame rates, and high-quality image acquisition.

Study group

Eligibility Criteria

• Age: 4 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

This prospective observational study was conducted at the pediatric cardiology and nephrology units of Al-Hussain and Bab El-Shaaria University Hospitals, Al-Azhar University, Cairo, Egypt from January 2025 to August 2025.

You may qualify if:

• Age between 4 and 18 years.
• Children with chronic kidney disease (CKD) receiving regular hemodialysis for ≥1 year.

You may not qualify if:

• Presence of structural or congenital heart disease.
• Patients with poor echocardiographic window or arrhythmias interfering with image acquisition.

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

Al-Azhar University

Cairo, 11651, Egypt

Location

MeSH Terms

Conditions

Kidney Failure, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Paediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Study Record Dates

• First Submitted: June 25, 2026
• First Posted: July 1, 2026
• Study Start: January 1, 2025
• Primary Completion: August 1, 2025
• Study Completion: August 1, 2025
• Last Updated: July 1, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)