Association Between 4D MRI Parameters and the Clinical Characteristics and Prognosis of Major Chronic Diseases

NCT07678606 | Not Yet Recruiting

• 1 other identifier: UUH-4DFLOW-2026
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Cancer and cardiovascular diseases are among the leading causes of morbidity and mortality worldwide. Advanced imaging techniques such as 4D magnetic resonance imaging (MRI) enable quantitative assessment of hemodynamic and functional parameters beyond conventional imaging. The aim of this study is to evaluate the association between 4D MRI derived parameters and the occurrence, severity, and prognosis of major chronic diseases, and to explore their potential role as imaging biomarkers.

Conditions

Cardiovascular Disease; Cardiac Magnetic Resonance Imaging; Neoplasm

Keywords

Cardiovascular disease; Malignancy; Cardiac Magnetic Resonance Imaging; Hemodynamic parameters

Outcome Measures

Primary Outcomes (1)

• Incidence of Major Adverse Cardiovascular Events (MACE)

  Incidence of major adverse cardiovascular events, including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure during the follow-up period

  up to 10 years

Secondary Outcomes (2)

• Peak Wall Shear Stress

  Perioperative/Periprocedural

• Blood Flow Eccentricity

  Perioperative/Periprocedural

Study Arms (1)

Ulsan University Hospital, 4D MRI cohort

Adult patients aged 19 years and older undergoing clinically indicated Cardiac MRI at Ulsan University Hospital who provide written informed consent and undergo an additional 4D MRI sequence during the same imaging session.

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients aged 19 years and older undergoing clinically indicated cardiac MRI at Ulsan University Hospital (Ulsan, South Korea) will be included in the study population. Individuals who provide written informed consent and undergo an additional 4D MRI sequence during the same imaging session will be enrolled in this prospective observational registry.

You may qualify if:

• Adults aged 19 years and older undergoing clinically indicated Cardiac MRI at Ulsan University Hospital
• Participants who undergo an additional 4D MRI sequence during the same imaging session
• Participants who are able to understand the study and provide written informed consent

You may not qualify if:

• Individuals aged \< 19 years
• Individuals with cognitive impairment or communication difficulties unable to provide informed consent
• Poor-quality MRI images that are not suitable for analysis
• Individuals deemed inappropriate for study participation by the investigator

Sponsors & Collaborators

• Ulsan University Hospital: lead

Study Sites (1)

Ulsan University Hospital

Ulsan, 44033, South Korea

Location

MeSH Terms

Conditions

Cardiovascular Diseases; Neoplasms

Central Study Contacts

Gyung-Min Park MD, PhD

CONTACT

82-52-250-8993; gmpark@uuh.ulsan.kr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD

Study Record Dates

• First Submitted: June 24, 2026
• First Posted: July 1, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): February 29, 2036
• Study Completion (Estimated): February 28, 2046
• Last Updated: July 7, 2026

Record last verified: 2026-07

Locations

KR (1)