NCT07677111

Brief Summary

People differ in chronotype - whether they function best in the morning ("larks") or the evening ("owls"). This study asks whether the match or mismatch between a person's chronotype and the time of day at which they are tested changes how they perceive time. Healthy morning-type and evening-type adults at three sites (Aarhus, Denmark; Changzhou, China; and Hong Kong) complete the same battery of perception and cognition tasks twice - once in the early morning (about 08:00) and once late in the evening (about 22:00), in counterbalanced order. The primary outcome is the accuracy (signed bias) of time-perception judgements; the key comparison is the interaction between chronotype and time of day (the "synchrony effect"). Secondary measures include timing precision, the subjective passage of time, sleepiness, mood, colour perception (with and without blue-blocking glasses) and perceptual decision-making. By testing the same protocol across three cultures and latitudes, the study examines whether circadian match/mismatch effects on temporal cognition generalise across populations.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
240

participants targeted

Target at P75+ for not_applicable

Timeline
23mo left

Started Sep 2025

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress32%
Sep 2025Jun 2028

Study Start

First participant enrolled

September 1, 2025

Completed
10 months until next milestone

First Submitted

Initial submission to the registry

June 22, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

June 30, 2026

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2028

Last Updated

June 30, 2026

Status Verified

June 1, 2026

Enrollment Period

2.8 years

First QC Date

June 22, 2026

Last Update Submit

June 29, 2026

Conditions

Keywords

chronotypemorningness-eveningnesssynchrony effecttime perceptiontemporal cognitioncircadian rhythmtime-of-dayduration discriminationarousalcross-cultural

Outcome Measures

Primary Outcomes (1)

  • Time-perception bias measured by the two-alternative forced-choice duration-comparison point of subjective equality

    Participants complete a two-alternative forced-choice duration-comparison task. On each trial, they judge whether a comparison interval is shorter or longer than a standard interval. A psychometric function is fitted to each participant's responses to estimate the point of subjective equality, defined as the comparison duration judged longer than the standard on 50% of trials. Time-perception bias is calculated as signed percentage error: ((point of subjective equality - standard duration) / standard duration) × 100. Positive values indicate a point of subjective equality above the standard duration; negative values indicate a point of subjective equality below the standard duration. The primary comparison is the chronotype-by-session-time interaction, testing whether time-perception bias differs between circadian match and mismatch sessions.

    Each of two laboratory sessions, morning about 08:00 and evening about 22:00, completed within about 2 weeks.

Secondary Outcomes (7)

  • Temporal precision measured by the two-alternative forced-choice duration-discrimination Weber fraction

    Each of two laboratory sessions, morning about 08:00 and evening about 22:00, completed within about 2 weeks.

  • Subjective passage of time measured by a passage-of-time rating scale

    Each of two laboratory sessions, morning about 08:00 and evening about 22:00, completed within about 2 weeks.

  • Subjective sleepiness measured by the Karolinska Sleepiness Scale

    Each of two laboratory sessions, morning about 08:00 and evening about 22:00, completed within about 2 weeks.

  • Mood measured by the Multidimensional Mood Questionnaire

    Each of two laboratory sessions, morning about 08:00 and evening about 22:00, completed within about 2 weeks.

  • Unique-hue settings measured as hue angle in the Commission Internationale de l'Éclairage Colour Appearance Model 2016 (CIECAM16)

    Each of two laboratory sessions, morning about 08:00 and evening about 22:00, completed within about 2 weeks.

  • +2 more secondary outcomes

Study Arms (2)

Morning-first sequence

EXPERIMENTAL

Participants complete the Morning test session (about 08:00) first, then the Evening test session (about 22:00). Both sessions use the identical perception and cognition battery; session order is counterbalanced across participants.

Behavioral: Morning test session (about 08:00)Behavioral: Evening test session (about 22:00)

Evening-first sequence

EXPERIMENTAL

Participants complete the Evening test session (about 22:00) first, then the Morning test session (about 08:00). Both sessions use the identical perception and cognition battery; session order is counterbalanced across participants.

Behavioral: Morning test session (about 08:00)Behavioral: Evening test session (about 22:00)

Interventions

Full perception and cognition battery administered shortly after habitual wake (about 08:00): time-perception tasks (interval production/estimation, duration discrimination, passage-of-time judgement), state measures (sleepiness, mood, arousal), colour tasks, a perceptual conformity task, and a vigilance task.

Evening-first sequenceMorning-first sequence

The identical battery administered late in the evening (about 22:00), enabling within-participant comparison of the same measures at the two times of day.

Evening-first sequenceMorning-first sequence

Eligibility Criteria

Age18 Years - 55 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy adult, 18-40 years
  • Clear morning-type or evening-type on the Morningness-Eveningness Questionnaire (MEQ-SA); intermediate types excluded (state exact cut-offs, e.g. evening-type 41 or below, morning-type 59 or above)
  • Normal or corrected-to-normal visual acuity
  • Normal colour vision (e.g. Ishihara screening)
  • Fluent in the testing-site language (Danish, Chinese, or English)
  • Able to attend both an early-morning (about 08:00) and a late-evening (about 22:00) session

You may not qualify if:

  • Intermediate chronotype (MEQ in the middle band)
  • Night or rotating shift work in the past 3 months, or recent trans-meridian travel (more than 2 time zones in the past 4 weeks)
  • Diagnosed sleep disorder (e.g. insomnia, sleep apnoea)
  • Current psychiatric or neurological disorder
  • Use of sleep medication or psychoactive or CNS-active drugs
  • Colour-vision deficiency
  • Substance-use disorder

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Child Development Centre

Hong Kong, Hong Kong

RECRUITING

Related Publications (6)

  • Kuriyama K, Uchiyama M, Suzuki H, Tagaya H, Ozaki A, Aritake S, Shibui K, Xin T, Lan L, Kamei Y, Takahashi K. Diurnal fluctuation of time perception under 30-h sustained wakefulness. Neurosci Res. 2005 Oct;53(2):123-8. doi: 10.1016/j.neures.2005.06.006.

    PMID: 16039739BACKGROUND
  • Kuriyama K, Uchiyama M, Suzuki H, Tagaya H, Ozaki A, Aritake S, Kamei Y, Nishikawa T, Takahashi K. Circadian fluctuation of time perception in healthy human subjects. Neurosci Res. 2003 May;46(1):23-31. doi: 10.1016/s0168-0102(03)00025-7.

    PMID: 12725909BACKGROUND
  • Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989 May;28(2):193-213. doi: 10.1016/0165-1781(89)90047-4.

    PMID: 2748771BACKGROUND
  • Roenneberg T, Wirz-Justice A, Merrow M. Life between clocks: daily temporal patterns of human chronotypes. J Biol Rhythms. 2003 Feb;18(1):80-90. doi: 10.1177/0748730402239679.

    PMID: 12568247BACKGROUND
  • May CP, Hasher L. Synchrony effects in inhibitory control over thought and action. J Exp Psychol Hum Percept Perform. 1998 Apr;24(2):363-79. doi: 10.1037//0096-1523.24.2.363.

    PMID: 9554091BACKGROUND
  • Horne JA, Ostberg O. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int J Chronobiol. 1976;4(2):97-110.

    PMID: 1027738BACKGROUND

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Model Details: Each participant completes both a morning (about 08:00) and an evening (about 22:00) test session in counterbalanced order; the two arms are the two session orders. Chronotype (morning-type vs evening-type) is a prespecified between-subjects classification. The key comparison is the chronotype-by-time-of-day interaction (synchrony: match vs mismatch).
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Research Assistant Professor

Study Record Dates

First Submitted

June 22, 2026

First Posted

June 30, 2026

Study Start

September 1, 2025

Primary Completion (Estimated)

June 30, 2028

Study Completion (Estimated)

June 30, 2028

Last Updated

June 30, 2026

Record last verified: 2026-06

Data Sharing

IPD Sharing
Will share

De-identified individual participant data underlying the published results, together with the study protocol, statistical analysis plan, and analysis code, will be made openly available via the Open Science Framework (OSF).

Shared Documents
STUDY PROTOCOL, SAP, ANALYTIC CODE
Time Frame
Beginning after publication of the primary results, with no planned end date.
Access Criteria
Open access via the Open Science Framework; no application required.

Locations