Adapting the STRW Intervention for Adolescents and Young Adults With Epilepsy (ARGOS)

NCT07676539 | Active Not Recruiting

• 2 other identifiers: 2025-05795T32HD068223-13
• Study Type: interventional
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn if a telehealth intervention (Surviving and Thriving in the Real World; STRW) is helpful to improve daily living skills for teens and young adults with epilepsy. It will also learn about the acceptability, feasibility, and satisfaction of the intervention. The main questions it aims to answer are:

• Is STRW an acceptable, feasible, and satisfactory intervention for teens/young adults and their caregivers?
• Does STRW improve daily living skills (e.g., cooking, laundry, money management) for teens and young adults with epilepsy? This is a nonrandomized pilot trial and all participants who enroll will:
• Participate in weekly caregiver/teen dyads ( approximately 60 minutes) focused on improving daily living skills with a trained therapist for 15 weeks.
• Participate in weekly caregiver groups (approximately 90 minutes) focused on supporting caregivers in coaching their teens in daily living skills development led by 2 trained therapists for 14 of the 15 intervention weeks.
• Complete measures of adaptive functioning (to evaluate daily living skills; parent and teen-report) at the start of the study and post-intervention. Additional measures will also be collected.
• Have the option to complete post-intervention interviews to provide feedback on the intervention components.

Conditions

Epilepsy; Epilepsy in Youth; Activities, Daily Living

Keywords

Surviving and Thriving in the Real World; STRW; ARGOS; Daily Living Skills

Outcome Measures

Primary Outcomes (5)

• Enrollment Rate

  Enrollment rate will be calculated by dividing the number of consented participants by the number of eligible participants.

  Enrollment

• Retention Rate

  Retention will be calculated by dividing the number of participants who completed the study at post-treatment by the number of eligible participants enrolled.

  From enrollment to 1-month post intervention (up to approximately 23 weeks)

• Caregiver Satisfaction and Acceptability

  The study-specific satisfaction and acceptability surveys will be sent to caregivers after each caregiver group and dyad session attended in order to obtain timely feedback on aspects of the intervention. For each item, participants are asked to rate helpfulness of each treatment component on a 5-point scale with 1 indicating "not helpful" and 5 indicating "very helpful." Mean ratings across all sessions will be utilized to determine satisfaction and acceptability, with a mean of 4 or higher indicating overall satisfaction and acceptability in the trial.

  Weekly during the intervention (Up to 15 weeks)

• Adolescent/Young Adult Satisfaction and Acceptability

  The study-specific satisfaction and acceptability surveys will be sent to adolescent and young adult participants after each dyad session completed in order to obtain timely feedback on aspects of the intervention. For each item, participants are asked to rate helpfulness of each treatment component on a 5-point scale with 1 indicating "not helpful" and 5 indicating "very helpful." Mean ratings across all sessions will be utilized to determine satisfaction and acceptability, with a mean of 4 or higher indicating overall satisfaction and acceptability in the trial.

  Weekly during the intervention (Up to 15 weeks)

• Adaptive Behavior Assessment System, Third Edition (ABAS-3), Adult-Other (Caregiver) Form, Practical Domain Standard Score

  The ABAS-3 Adult-Other (Caregiver) Form, Practical Domain Standard Score will be used as a primary outcome measure. The standard score is calculated based on the sum of scaled scores for each of the skill areas. The standard scores typically range from 70 to 120, with a mean of 100 and a standard deviation of 10. Higher scores equate to better adaptive skills.

  Post-Intervention (Up to 4 weeks Post-Intervention)

Secondary Outcomes (1)

• Adaptive Behavior Assessment System, Third Edition (ABAS-3), Adult-Self Form, Practical Domain Standard Score

  Post-Intervention (Up to 4 weeks Post-Intervention)

Study Arms (1)

Surviving and Thriving in the Real World

EXPERIMENTAL

Participants in this single arm receive the study intervention (Surviving and Thriving in the Real World (STRW)).

Behavioral: Surviving and Thriving in the Real World

Interventions

Surviving and Thriving in the Real World BEHAVIORAL

The Surviving and Thriving in the Real World (STRW) intervention consists of 15 weekly caregiver-teen dyad sessions and 14 concurrent weekly caregiver group sessions delivered via Microsoft Teams. Daily Living Skills (DLS) targeted in the intervention include: morning routine, laundry, kitchen/cooking, grocery shopping, and money management. Evidence-based strategies are utilized to facilitate acquisition, mastery, and generalization of specific DLS at home and in the community. During dyad sessions, teens work on DLS in their home environment and will receive coaching and instruction from both their caregiver and the therapist. During caregiver group sessions, the therapist will discuss the content of dyad sessions and engage in problem solving with each caregiver.

Also known as: STRW

Surviving and Thriving in the Real World

Eligibility Criteria

• Age: 14 Years - 19 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• diagnosed with epilepsy at least 1 year ago,
• enrolled in 9th-12th grade (i.e., 14-18 years old at time of enrollment)
• deficits in adaptive functioning per caregiver report (i.e., standard score below 90 on either the ABAS-3 Practical Domain or General Adaptive Composite \[GAC\]),
• not planning to wean off anti-seizure medication (ASM) within the intervention timeframe,
• and family's primary language is English.

You may not qualify if:

• Parent- or clinician-reported history in the adolescent/young adult of:
• history of developmental delay (e.g., autism spectrum disorder, pervasive development disorder, history of services for developmental delay or intellectual impairment in the past 5 years, known IQ\<70),
• severe mental illness (e.g., schizophrenia, bipolar disorder, eating disorder within the past 12 months),
• currently on the ketogenic diet,
• and history of epilepsy surgery in the past year.
• Clinician-reported diagnosis in the adolescent/young adult of:
• one or more episodes of status epilepticus within the 24 weeks prior to enrollment
• treatable causes of seizures (for example, identified etiologies including metabolic, neoplastic or active infectious origin),
• a confirmed or suspected epileptic encephalopathy (e.g., electrical status epilepticus in sleep, Landau Kleffner syndrome, West syndrome),
• a confirmed or suspected progressive and degenerative disorder (e.g., mitochondrial disorders, metabolic disorders, autoimmune disorders),
• non-epileptic events/seizures.

Sponsors & Collaborators

• Children's Hospital Medical Center, Cincinnati: lead
• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): collaborator

Study Sites (1)

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States

Location

Related Links

• STRW Website

MeSH Terms

Conditions

Epilepsy; Motor Activity

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Behavior

Study Officials

• Avani Modi, Ph.D.

  Children's Hospital Medical Center, Cincinnati

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The proposed study will involve a single site nonrandomized pilot trial using pre-post design to assess the acceptability, feasibility, and satisfaction of the Surviving and Thriving in the Real World (STRW) intervention with teens and young adults with epilepsy and determine the impact of STRW on daily living skills.

Study Record Dates

• First Submitted: June 24, 2026
• First Posted: June 30, 2026
• Study Start: December 3, 2025
• Primary Completion: July 1, 2026
• Study Completion: July 1, 2026
• Last Updated: July 8, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)