Effectiveness of Early Intervention With Virtual Reality-Based Interactive Rehabilitation on Upper Extremity Muscle Strength, Cognitive Status, Hospital Anxiety, and Exercise Self-Efficacy in Patients With Acute Ischemic Stroke

NCT07674329 | Recruiting DMC

• 1 other identifier: C202405171
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This interventional study evaluates the impact of early virtual rehabilitation, starting 24 hours post-diagnosis of acute ischemic stroke, on upper limb strength, cognitive status, and self-efficacy. The goal is to establish more effective rehabilitation protocols for acute ischemic stroke patients and to boost their motivation to participate in training.

Conditions

Acute Ischemic Stroke

Keywords

Virtual reality, acute ischemic stroke, early rehabilitation, upper limb muscle strength, cognitive status, self-efficacy, anxiety

Outcome Measures

Primary Outcomes (2)

• upper limbs function

  FMA-UE

  7days later

• cognitive status

  SLUME

  7days later

Secondary Outcomes (1)

• Change in Self-Efficacy for Exercise (SEE) Scale Score

  Baseline and 7 days after intervention

Study Arms (2)

Early intervention in patients with acute ischemic stroke

EXPERIMENTAL

virtual reality-based interactive rehabilitation

Device: Virtual reality-based interactive rehabilitation

traditional rehabilitation.

EXPERIMENTAL

traditional bedside rehabilitation.

Behavioral: bedside rehabilitation

Interventions

Virtual reality-based interactive rehabilitation DEVICE

Virtual reality

Early intervention in patients with acute ischemic stroke

bedside rehabilitation BEHAVIORAL

traditional bedside rehabilitation

traditional rehabilitation.

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of acute ischemic stroke with ICD-10 codes: G45-G46.8, I63-I68.8.
• Within 10 days (inclusive) of stroke symptom onset.
• Age 18\~85 years or older.

You may not qualify if:

• Comorbid neuromuscular or orthopedic conditions affecting upper limb function.)
• Recurrence of stroke or onset of seizures during the study period.
• Severe visual impairment or visuospatial neglect.
• Inability to cooperate or refusal to participate in the study.

Sponsors & Collaborators

• Tri-Service General Hospital (TSGH): lead

Study Sites (1)

Tri Service General Hospital

Taipei, 224, Taiwan

RECRUITING

MeSH Terms

Conditions

Ischemic Stroke; Anxiety Disorders

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Mental Disorders

Study Officials

• YUN QIAN LIN

  Tri-Service General Hospital (TSGH)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

YUN QIAN LIN

CONTACT

28973311; yurilin0709@gmail.com

Hui-Chen LIN

CONTACT

cecilia@tmu.edu.tw

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Nurse Practitioner

Model Details: Participants in the experimental group will receive rehabilitation intervention using the Active Arcade application. They will perform interactive exercises on a tablet to complete combined motor and cognitive training. The control group will receive traditional bedside rehabilitation. Both groups will initiate their respective interventions 24 hours after admission. Pre- and post-test evaluations will be conducted for both groups to assess the effectiveness of the interventions.

Study Record Dates

• First Submitted: May 6, 2026
• First Posted: June 29, 2026
• Study Start: March 7, 2025
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: June 29, 2026

Record last verified: 2026-06

Locations

TW (1)