Sevoflurane Versus Propofol for Laryngeal Mask Airway Placement in Children Undergoing Surgery

NCT07673003 | Completed Phase 4

• 1 other identifier: U1111-1342-4662
• Study Type: interventional
• Target: 170
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to compare two commonly used anesthetic medicines, sevoflurane and propofol, for inserting a laryngeal mask airway (LMA) in children undergoing minor elective surgery. A laryngeal mask airway is a device placed in the throat to help children breathe safely during anesthesia. The main questions this study aims to answer are:

• Does sevoflurane produce a faster onset of anesthesia than propofol?
• Is there a difference between sevoflurane and propofol in the time required to achieve jaw relaxation for LMA insertion?
• Is there a difference between the two medicines in the time required for successful LMA insertion? The researchers hypothesize that children receiving sevoflurane will have a shorter induction time than those receiving propofol. A total of 170 children aged 4 to 12 years who are undergoing minor surgical procedures below the umbilicus will participate in the study. Participants will be randomly assigned to receive either intravenous propofol or inhaled sevoflurane for induction of anesthesia. During the procedure, the anesthesia team will measure the time taken to lose consciousness, the time required to achieve adequate jaw relaxation, and the time needed for successful insertion of the laryngeal mask airway. These measurements will help determine which anesthetic agent provides better conditions for LMA insertion in children.

Conditions

General Anaesthesia; Airway Devices; Airway Control

Keywords

Sevoflurane; Propofol; Laryngeal Mask Airway; Pediatric Anesthesia; Jaw Relaxation; Elective Surgery

Outcome Measures

Primary Outcomes (1)

• Time to Induction of Anesthesia

  Time (in seconds) measured from administration of the induction agent (propofol or sevoflurane) to loss of consciousness, defined as loss of verbal response and loss of eyelash reflex in pediatric patients undergoing elective surgery for laryngeal mask airway insertion.

  From administration of the induction agent until loss of consciousness, assessed for up to 5 minutes after induction.

Other Outcomes (2)

• Time to Jaw Relaxation

  From administration of the induction agent until achievement of adequate jaw relaxation (mouth opening >4 cm), assessed for up to 5 minutes after induction.

• Time to Laryngeal Mask Airway (LMA) Insertion

  From administration of the induction agent until successful laryngeal mask airway insertion, assessed for up to 5 minutes after induction.

Study Arms (2)

Propofol Group

ACTIVE COMPARATOR

Children in this group will receive intravenous propofol as the induction agent for general anesthesia prior to laryngeal mask airway (LMA) insertion.

Drug: propofol

Sevoflurane Group

EXPERIMENTAL

hildren in this group will receive inhalational sevoflurane for induction of general anesthesia prior to laryngeal mask airway (LMA) insertion.

Drug: Sevoflurane

Interventions

propofol DRUG

Intravenous propofol 3 mg/kg bolus will be administered for induction of general anesthesia before LMA insertion in pediatric patients.

Propofol Group

Sevoflurane DRUG

Sevoflurane 7% will be delivered via inhalation in a nitrous oxide/oxygen mixture (2:1) for induction of general anesthesia prior to LMA insertion in pediatric patients.

Sevoflurane Group

Eligibility Criteria

• Age: 4 Years - 12 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• ASA physical status 1 and 2
• Undergoing elective minor surgical procedures below umbilicus
• Procedure lasting less than 60 min

You may not qualify if:

• Recent respiratory tract infection
• Bronchial asthma
• Family history of malignant hyperthermia

Sponsors & Collaborators

• Children's Hospital and Institute of Child Health, Multan: lead

Study Sites (1)

Children's Hospital and Institute of Child Health Multan

Multan, Punjab Province, 60000, Pakistan

Location

MeSH Terms

Interventions

Propofol; Sevoflurane

Intervention Hierarchy (Ancestors)

Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Methyl Ethers; Ethers; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated

Study Officials

• Syed S Abbas, FCPS

  Children's Hospital and Institute of Child Health, Multan

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 17, 2026
• First Posted: June 29, 2026
• Study Start: June 1, 2025
• Primary Completion: November 30, 2025
• Study Completion: November 30, 2025
• Last Updated: June 29, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)