NCT07670117

Brief Summary

The purpose of this research is to assess whether integration of an aerosol biosensor and air quality risk assessment software that integrates into a building management system will improve indoor air quality metrics in hospital environments and reduces risk factors associated with respiratory disease transmission.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
850

participants targeted

Target at P75+ for not_applicable

Timeline
37mo left

Started Oct 2026

Typical duration for not_applicable

Geographic Reach
1 country

3 active sites

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 19, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

June 26, 2026

Completed
3 months until next milestone

Study Start

First participant enrolled

October 1, 2026

Expected
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2029

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2029

Last Updated

June 29, 2026

Status Verified

June 1, 2026

Enrollment Period

3 years

First QC Date

June 19, 2026

Last Update Submit

June 25, 2026

Conditions

Acute Respiratory Tract Infection

Outcome Measures

Primary Outcomes (1)

  • Number of participants to experience acute respiratory infection (ARI) symptoms

    Symptoms include: at least 2 upper respiratory symptoms for at least 24 hours; OR at least 2 symptoms that include an upper/lower respiratory symptom and a systemic symptom (fever, fatigue, body aches, headache, decreased appetite) for at least 24 hours

    3 years

Secondary Outcomes (2)

  • Number of confirmed cases of acute respiratory infections

    3 years

  • Number of confirmed cases of lower respiratory tract disease

    3 years

Study Arms (1)

Emergency Department Employees

EXPERIMENTAL

Emergency Department employees will act as the target group with the Emergency Department building implementing the HAIQU air quality sensor.

Diagnostic Test: Self-swab test

Interventions

Self-swab testDIAGNOSTIC_TEST

Participants will self-report when they are experiencing respiratory symptoms and will be asked for a self-swab to be used for data analysis.

Emergency Department Employees

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Target Group:
  • Mayo Clinic Staff working in ED with a minimum of .7 FTE in Midwest (MN and WI), Phoenix (AZ), or Jacksonville (FL) and patient contact.
  • Reference Group:
  • Mayo Clinic Staff working in primary care with a minimum of .7 FTE. in Rochester (MN), Phoenix (AZ), or Jacksonville (FL) and patient contact

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Mayo Clinic Arizona

Phoenix, Arizona, 85054, United States

Location

Mayo Clinic Florida

Jacksonville, Florida, 32224, United States

Location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Location

Study Officials

  • Connie Chang, Ph.D.

    Mayo Clinic

    PRINCIPAL INVESTIGATOR

  • Chung Wi, M.D.

    Mayo Clinic

    PRINCIPAL INVESTIGATOR

Central Study Contacts

HAIQU Research Staff

CONTACT

507-422-3077BreatheResearch@mayo.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Masking Details
There is no masking in this study.
Purpose
PREVENTION
Intervention Model
SINGLE GROUP
Model Details: This study will use a prospective cohort study design (single arm) to evaluate the association between the incidence of acute respiratory infections (ARI) and pathogens in indoor air quality detected through either manual biosampling or the HAIQU biosensor. The investigators will estimate the incidence of ARI in approximately 600 (minimum: 300) adults (\>=18 years) working in Emergency Department of Mayo Clinic (Midwest (MN, WI), FL, and AZ). After completion of subject recruitment (Year 1) for this Target group, ARI in Year 2 will serve as baseline (pre-intervention for the building) data, followed by Year 3 for supporting development and optimization of building intervention and Year 4 for post-intervention data. To account for secular trends that affect ARI incidence independent of the intervention (e.g. changes in infection patterns, medical practice, testing methods), the investigators will recruit an additional 250 adults (min 150) working in primary care settings (MN, FL, AZ).
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor of Biomedical Engineering

Study Record Dates

First Submitted

June 19, 2026

First Posted

June 26, 2026

Study Start (Estimated)

October 1, 2026

Primary Completion (Estimated)

September 30, 2029

Study Completion (Estimated)

September 30, 2029

Last Updated

June 29, 2026

Record last verified: 2026-06

Data Sharing

IPD Sharing
Will not share

Individual participant data (IPD) will not be shared because the study collects detailed longitudinal health, occupational, and location-related information from Mayo Clinic employees. Although data will be coded for research purposes, the combination of respiratory health outcomes, workplace characteristics, and real-time location system (RTLS) data may increase the risk of participant re-identification. To protect participant privacy, confidentiality, and institutional data security requirements, individual-level datasets will not be made available to external researchers. Aggregate and de-identified study results will be reported through scientific publications and presentations in accordance with applicable regulations and institutional policies.

Locations

US(3)