Impact of E-Cigarette Smoking on Healing Response to Non-Surgical Periodontal Therapy

NCT07668947 | Completed DMC

• 1 other identifier: 1449
• Study Type: interventional
• Target: 117
• Locations: 1 country
• Sites: 1

Brief Summary

the goal of this clinical trial is to compare the effect of vaping vs traditional smoking on non surgical periodontal therapy . the main question it aims to answer is what is the impact of traditional smoking and vaping on periodontal health and how do IL-1B and IL-20 serve as mediators in the inflammatory processes linked to periodontal disease?

Conditions

Periodontitis

Keywords

periodontitis; smoking; e-cigarette; GCF

Outcome Measures

Primary Outcomes (4)

• probing depth (PD)

  assessment of periodontal probing depth measured in millimeters using a UNC -15 periodontal probe. PD will be measured from the gingival margin to the base of the periodontal pocket at six sites per tooth

  baseline and 2 months follow up

• clinical attachment loss

  assessment of CAL measured in millimeters using a UNC-15 periodontal probe. CAL will be measured from (CEJ) to the base of the pocket at 6 sites per tooth

  baseline and 2 months follow up after non surgical periodontal surgery

• plaque index

  assessment of plaque accumulation using plaque index ( Silness and Loe plaque index )

  baseline and 2 months follow up after NSPT

• bleeding on probing

  assessment of gingival bleeding following periodontal probing and recorded as the percentage of bleeding sites.

  baseline and 2 months follow up after NSPT

Secondary Outcomes (2)

• interleukin-1B level in GCF

  baseline and 2 months after NSPT

• IL-20 level in GCF

  baseline and 2 month after NSPT

Study Arms (3)

traditional smokers

ACTIVE COMPARATOR

patients with stage II periodotitis who are conventional cigarette smokers and recieved non surgical periodontal therapy

Procedure: non surgical periodontal therapy

e-cigarette smokers

ACTIVE COMPARATOR

pts with stage II periodontitis who are on e-cigarette smoking and recieved non surgical periodontal therapy

Procedure: non surgical periodontal therapy

non smokers

ACTIVE COMPARATOR

pts with stage II periodontitis who are non smokers and recieved non surgical periodontal therapy

Procedure: non surgical periodontal therapy

Interventions

non surgical periodontal therapy PROCEDURE

participants in all groups will recieve non surgical periodontal therapy including scaling and root planning performed using ultrasonic and hand instruments at baseline. oral hygiene instructions will be provided. periodontal parameters and GCF samples will be collected at baseline and follow up visit.

e-cigarette smokers; non smokers; traditional smokers

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• pts aged 20-40 years
• pts with stage II periodontitis
• systemically healthy with no chronic diseases
• no current use of medication
• participants have the same socioeconomic status
• participants must be able to understand and comply with the study protocol and give informed consent

You may not qualify if:

• pts with severe systemic diseases
• recent use of immunosuppressants or medications that affect oral health
• history of illicit drug use within the past 12 months
• periodontal surgery or scaling within the last 6 months
• participants in another clinical trial
• vulnerable individuals as children and pregnant

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

faculty of dentistry , Ain shams university

Cairo, Cairo Governorate, 11566, Egypt

Location

Related Links

• pubmed article

MeSH Terms

Conditions

Periodontitis; Smoking; Vaping

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Behavior

Study Officials

• Mohamed M Al Bahrawy, Assoc. pro

  faculty of dentistry ,Ain shams university

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 16, 2026
• First Posted: June 25, 2026
• Study Start: October 13, 2025
• Primary Completion: December 21, 2025
• Study Completion: March 4, 2026
• Last Updated: July 1, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)