The Effects, Usability, Satisfaction, Barriers, and Benefits of a Remote, Multidomain Website-based Intervention to Prevent Cognitive Decline in Older Adults

NCT07668440 | Not Yet Recruiting DMC

• 1 other identifier: 2026-785-046
• Study Type: interventional
• Target: 71
• Locations: 1 country
• Sites: 1

Brief Summary

Mexico exhibits a high prevalence of dementia, exceeding 8%, and it is estimated that by 2050 around 3.5 million older adults will be living with this condition. In light of this scenario, addressing factors associated with dementia development through preventive strategies is a priority, particularly through multicomponent programs that integrate physical activity, cognitive training, and other lifestyle-modification components, implemented early before the onset of clinical symptoms. To expand access to this type of intervention for older adults with limited time or resources for in-person care, remote preventive programs delivered by digital media have been launched. Web platforms constitute an accessible and cost-effective alternative for delivering complex interventions, such as the "Mind and Movement for Cognitive Health (MeMo-Salud-Cog)" program, which is designed to promote lifestyles conducive to cognitive health and has shown promising preliminary results in overall cognitive function, memory, executive function, and attention. However, the use of digital systems by older adults may be limited by barriers associated with aging (cognitive, sensory, physical, and motivational), as well as social factors (education and social isolation) or cultural factors (beliefs and perceived usefulness), which can affect the continuity of their participation. In this context, the present proposal suggests adapting the MeMo-Salud-Cog program to a remote modality, through a website and remote monitoring by healthcare professionals, with the aim of evaluating its feasibility based on usability, satisfaction, effect, and adherence, as well as analysing perceived acceptability, with an emphasis on the barriers and benefits of remote intervention. The investigators will employ a mixed design combining quantitative and qualitative methods, with a pre-post evaluation without a control group in the quantitative part and semi-structured interviews in the qualitative part (pilot study). The study population will consist of independent individuals aged 60 to 75 years affiliated with IMSS at Family Medicine Units 1 and 28, with or without cognitive complaints but without impairment (MMSE ≥ 24), with functional independence, at least one vascular risk factor, a mobile phone or computer, and a signed informed consent form.

Conditions

Coginitive Dysfunction

Keywords

Exercise; Cognitive Training; cognition; cognitive impairment; older adults; prevention

Outcome Measures

Primary Outcomes (6)

• Subjective cognitive enhancing.

  Through a questionnaire, the subjective memory complaint will be assessed by responding positively (≥1) or negatively (≤0) to questions such as: Do you feel you have trouble remembering things? Do you forget conversations? Do you repeat the same questions several times? Have you recently forgotten to turn off the stove? Do you think you have memory problems? Higher scores mean worse outcomes.

  Measurements will be taken on Day 0 and Month 3. The difference between these two will be calculated.

• Cognitive enhancers-global-MoCA

  The assessment will be conducted using: a) The Montreal Cognitive Assessment (MoCA), which scores from 0 to 30 points, and higher scores indicate a better outcome.

  Measurements will be taken on Day 0 and Month 3. The difference between these two will be calculated.

• Cognitive enhancers-psycological (executive function and mental flexibility)

  Executive function and mental flexibility will be assessed using the Trail Making Tests, Part A and Part B (TMT-A and TMT-B). The results of these tests are expressed as the time, in seconds, each task takes to complete. Processing speed, measured with the Digit Symbol Substitution Test (DSST), will be determined by the total number of correct number matches (higher scores indicate better performance). Higher scores indicate a worse outcome. And symbols achieved in 90 seconds (higher scores mean a worse outcome).

  Measurements will be taken on Day 0 and Month 3. The difference between these two will be calculated.

• Cognitive enhancers-global-Blessed

  The Blessed Dementia Scale (Spanish version) comprises three sections: i) changes in daily activities (8 questions), ii) changes in habits (3 questions), and iii) changes in personality, interests, and impulses (11 questions), with a total score ranging from 0 to 28 (higher scores mean worse outcome).

  Measurements will be taken on Day 0 and Month 3. The difference between these two will be calculated.

• Cognitive enhancers-psychological (memory)

  Everyday memory will be evaluated with the Rivermead Behavioral Memory Test (RBMT). This test uses a scale from 0 to 12 points, based on subtests that cover: recalling names, personal objects, and appointments; recognizing images and faces; recalling stories, routes, and messages immediately and after a delay; and orientation and date (higher scores indicate a better outcome).

  Measurements will be taken on Day 0 and Month 3. The difference between these two will be calculated.

• Cognitive enhancers-psychological (verbal fluency)

  Verbal fluency (including semantic, animal naming, and phonetic fluency) will be assessed using the Controlled Oral Word Association Test (COWA). It will be determined by the total number of words identified in each category and letter (higher scores indicate a better outcome).

  Measurements will be taken on Day 0 and Month 3. The difference between these two will be calculated.

Secondary Outcomes (1)

• Digital usability

  Measurements will be collected at 1 and 3 months, and the difference between the two assessments will be calculated.

Other Outcomes (3)

• Perception of the risk and severity of memory decline or loss.

  Up to 12 weeks

• Perception of barriers to intervention.

  Up to 12 weeks.

• Perception of benefits and suggestions to intervention.

  Up to 12 weeks.

Study Arms (1)

MeMo-Health-Cog- remote

OTHER

MeMo-Health-Cog- remote

Other: Multi-domain intervention: Physical activity, cognitive training, and educational program through a website

Interventions

Multi-domain intervention: Physical activity, cognitive training, and educational program through a website OTHER

MeMo- Health- Cog Remote is a Multidomain intervention lasting 60 minutes, comprising 30 minutes of aerobic exercise, 20 minutes of cognitive training, and 5 minutes each for warm-up and cool-down. It is delivered at least three times weekly for 12 weeks. The weekly educational topic can also be reviewed on the same page, covering subjects such as active aging, healthy eating, and socialization. Participants access the program through a website, with options to watch the videos on TV.

MeMo-Health-Cog- remote

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• With and without cognitive complaints (i.e., they have responded 'yes' to the question: 'Do you feel that your memory or learning abilities have worsened recently?").
• They demonstrate independence in activities of daily living and instrumental activities of daily living. • With one or more vascular risk factors (for example, type 2 diabetes or hypertension).
• With a score on the overall cognitive function test of≥ 24 on the Mini-Mental State Examination.
• With a score between 0-4 on the Blessed Dementia Scale.
• With a mobile phone or computer.
• Have a companion, such as a child, spouse, or friend, who can support you during the assessment in case of an emergency.
• Voluntary acceptance to participate in the study through a signed informed consent form prior to your participation.

You may not qualify if:

• Depression (score \> 15 according to the Epidemiological Studies Center Depression Scale - Revised \[CESD-R\]).
• With a clinical diagnosis of any significant neurological or psychiatric disorder (for example, Parkinson's disease, schizophrenia).
• With any heart disease.
• Presence of a recent cancer diagnosis.
• History of recent severe cardiovascular event (for example, myocardial infarction, stroke).
• Significant orthopedic conditions (for example, severe osteoarthritis).
• Uncontrolled blood pressure (very high \> 180/100 mmHg or very low \< 100/60 mmHg).
• Severe visual or hearing impairment.
• Type 2 Diabetes Mellitus requires insulin to control hyperglycemia.

Sponsors & Collaborators

• Instituto Mexicano del Seguro Social: lead

Study Sites (1)

Avenida Cuahutémoc 330

Mexico City, Mexico City, 06401, Mexico

Location

Related Publications (11)

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MeSH Terms

Conditions

Motor Activity; Cognitive Dysfunction

Interventions

Cognitive Training

Condition Hierarchy (Ancestors)

Behavior; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Neurological Rehabilitation; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Central Study Contacts

Rosalinda Senior Researcher A, PhD

CONTACT

+52 5556276900; felicitasarenas@gmail.com

Jessica Camacho Ruíz, M.Sc

CONTACT

+55 2227089824; jeskaru81@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: No masking
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Investigator in Epidemiology

Model Details: Clinical trials with a single arm

Study Record Dates

• First Submitted: June 5, 2026
• First Posted: June 25, 2026
• Study Start: July 6, 2026
• Primary Completion (Estimated): July 2, 2027
• Study Completion (Estimated): October 29, 2027
• Last Updated: July 28, 2026

Record last verified: 2026-07

Locations

ME (1)