NCT07664982

Brief Summary

The investigators aim to undertake the Global Reference Range Study (GRR) to establish a set of healthy adult reference values for measures of fibroinflammation, fat and size/volumes for the liver, and other abdominal and thoracic organs to assess, compare, and if necessary, propose ethnicity specific reference ranges for these measurements.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for all trials

Timeline
37mo left

Started Aug 2026

Typical duration for all trials

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 12, 2026

Completed
12 days until next milestone

First Posted

Study publicly available on registry

June 24, 2026

Completed
1 month until next milestone

Study Start

First participant enrolled

August 1, 2026

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2029

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2029

Last Updated

June 24, 2026

Status Verified

June 1, 2026

Enrollment Period

3 years

First QC Date

June 12, 2026

Last Update Submit

June 17, 2026

Conditions

Healthy Adult Participants

Outcome Measures

Primary Outcomes (1)

  • Reference intervals for liver cT1

    Measured using Perspectum's LiverMultiScan

    24 months

Secondary Outcomes (8)

  • Reference intervals for liver PDFF, iron and volume

    24 months

  • Reference intervals for pancreas T1 and PDFF

    24 months

  • Reference intervals for kidney cortical T1 and renal sinus fat volume (RSFV)

    24 months

  • Reference intervals for measures of body composition

    24 months

  • Reference intervals for cardiac volumes and function

    24 months

  • +3 more secondary outcomes

Eligibility Criteria

Age18 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Healthy volunteers, aged 18 years and over.

You may qualify if:

  • Male or female at least 18 years of age
  • Self-reported healthy
  • Willing and able to give informed consent for participation in the study
  • Willing and able to undergo an MRI

You may not qualify if:

  • History of cardiovascular disease as follows:
  • Myocardial infarction
  • Heart failure
  • Cardiomyopathy
  • Stroke
  • Hospital admission/discharge for unstable angina
  • Heart surgery
  • Unstable angina
  • Transient ischemic attack
  • Presence of CVD risk factors such as hypertension, hyperlipidaemia, Type 2 diabetes, BMI \> 30 kg/m2, smoker (current/ex-smoker)
  • History of non-cardiac diseases related to the lungs, liver, kidneys, pancreas or spleen judged by the study investigator as therefore unsuitable to participate in the study
  • Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the participant's ability to participate in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 12, 2026

First Posted

June 24, 2026

Study Start

August 1, 2026

Primary Completion (Estimated)

August 1, 2029

Study Completion (Estimated)

August 1, 2029

Last Updated

June 24, 2026

Record last verified: 2026-06