NCMT Technique and Jodhpur Technique and Excimer Laser in Treatment of Non Vitiligo Leucoderma

NCT07662915 | Not Yet Recruiting

• 1 other identifier: RESEARCH/AZ.AST./DVA021/10/265
• Study Type: interventional
• Target: 22
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to compare the efficacy and safety of Melanocyte Keratinocyte Transplantation Procedure (MKTP) combined with 308-nm excimer laser versus Jodhpur technique combined with 308-nm excimer laser in the treatment of stable non-vitiligo leukoderma. Twenty-two patients with stable depigmented lesions will be enrolled. In each patient, two comparable lesions will be treated using different techniques. Clinical outcomes including percentage of repigmentation, color match, time to onset of repigmentation, complications, and histological changes will be assessed during follow-up to determine the optimal surgical treatment approach for non-vitiligo leukoderma.

Conditions

Leukoderma

Outcome Measures

Primary Outcomes (1)

• Mean Percentage Repigmentation of Target Lesions

  6 months

Secondary Outcomes (2)

• Time to Onset of Repigmentation

  Up to 6 months

• Color Match Assessment

  6 months

Study Arms (2)

MKTP+ excimer laser

EXPERIMENTAL

Melanocyte Keratinocyte Transplantation Procedure followed by 308-nm excimer laser therapy

Procedure: Melanocyte Keratinocyte Transplantation Procedure (MKTP); Device: 308-nm Excimer Laser

Jodhpur Technique + Excimer Laser

EXPERIMENTAL

Jodhpur technique followed by 308-nm excimer laser therapy

Procedure: Jodhpur Technique; Device: 308-nm Excimer Laser

Interventions

Melanocyte Keratinocyte Transplantation Procedure (MKTP) PROCEDURE

Autologous melanocyte-keratinocyte cell suspension prepared using enzymatic separation and applied to a dermabraded recipient site.

MKTP+ excimer laser

Jodhpur Technique PROCEDURE

Autologous non-cultured epidermal cell transfer technique using dermabraded donor skin particles applied directly to the recipient site without enzymatic processing

Jodhpur Technique + Excimer Laser

308-nm Excimer Laser DEVICE

Excimer laser therapy initiated approximately 14 days after surgery, administered twice weekly for 12-16 weeks with dose adjustment according to erythema response

Jodhpur Technique + Excimer Laser; MKTP+ excimer laser

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18 to 60 years.
• Clinically diagnosed stable non-vitiligo leukoderma.
• Stable lesion(s) for at least 6 months with no progression.
• Inadequate response to conventional medical therapy.
• Presence of two comparable lesions
• Willingness to participate and provide written informed consent.

You may not qualify if:

• Vitiligo or suspected active vitiligo.
• History of keloid or hypertrophic scar formation.
• Active infection at donor or recipient sites.
• Bleeding disorders or anticoagulant therapy that cannot be safely discontinued.
• Pregnancy or lactation.
• Immunosuppression or uncontrolled systemic disease.
• Inability to comply with follow-up visits.
• Unrealistic expectations regarding treatment outcome.

Sponsors & Collaborators

• Al-Azhar University: lead

MeSH Terms

Conditions

Vitiligo

Interventions

Lasers, Excimer

Condition Hierarchy (Ancestors)

Hypopigmentation; Pigmentation Disorders; Skin Diseases; Skin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Lasers; Optical Devices; Equipment and Supplies; Radiation Equipment and Supplies

Central Study Contacts

Mohamed Mahmoud

CONTACT

+201091865997; mas912m@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD researcher

Study Record Dates

• First Submitted: June 17, 2026
• First Posted: June 23, 2026
• Study Start: July 1, 2026
• Primary Completion: July 1, 2026
• Study Completion (Estimated): September 1, 2027
• Last Updated: June 23, 2026

Record last verified: 2026-06