NCT07661355

Brief Summary

This study investigates better ways to help people after they leave the hospital and how to involve their families in this process. The main goal is to see if adding family support to a patient-centered hospital-to-home intervention helps patients stay safely at home, spend fewer days back in the emergency room or going back into the hospital. The study team also wants to see if the family-centered approach helps improve the patient's ability to do everyday activities without feeling overwhelmed. Two approaches are being compared: one focuses just on the patient, and the other includes special strategies to better support families involved too. Family will be involved in assessing what the patient and family needs. The family-focused approach not only emphasizes the experience, health, and safety of the patient but also the experience of the family member caring for the older adult. The study also involves families in education and provides families skills-building experiences that can help with caregiving stress, problem-solving, and communicating with the healthcare team. The approach will help the family member prepare for their loved one's transition home and provide coaching with the goal of reducing the mental, physical and financial burden of providing care at home. To spread the intervention across many states, the study team will be using telephone calls, video calls, and other technologies as families prefer.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,560

participants targeted

Target at P75+ for not_applicable

Timeline
64mo left

Started Jul 2026

Longer than P75 for not_applicable

Geographic Reach
1 country

4 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress1%
Jul 2026Nov 2031

First Submitted

Initial submission to the registry

June 16, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

June 22, 2026

Completed
1 month until next milestone

Study Start

First participant enrolled

July 22, 2026

Completed
5.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2031

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2031

Last Updated

July 31, 2026

Status Verified

May 1, 2026

Enrollment Period

5.3 years

First QC Date

June 16, 2026

Last Update Submit

July 29, 2026

Conditions

Keywords

hospitalizationolder adultsagingcare transitionmild cognitive impairment

Outcome Measures

Primary Outcomes (1)

  • Hospital-Free Days

    The count of days alive and outside acute care hospitals from discharge to day 60. It will be calculated using EHR and Medicare claims data to objectively capture hospital free days elements (i.e.: mortality days, inpatient days, observation stays, and ED visits).

    Day 60

Secondary Outcomes (19)

  • Number of Hospital-Free Days

    Day 30, 90, and 180

  • Number of Patient Readmissions

    Day 30, 60, and 90

  • Zarit Burden Interview Score

    Day 60

  • Zarit Burden Interview Score

    Day 30, 90, and 180

  • PROMIS Ability to Participate in Social Roles and Activities 8-item short form (APS-SF8) Score

    Day 60

  • +14 more secondary outcomes

Study Arms (2)

Patient Focused Strategies

ACTIVE COMPARATOR

An active care transition program that includes effective strategies focused on the patient.

Other: Patient-Centered Program

Patient and Family Focused Strategies

EXPERIMENTAL

An active care transition program that includes effective strategies focused on the patient plus focused family caregiver engagement and support.

Other: Patient-Centered ProgramOther: Family Caregiver Enhanced Program

Interventions

Effective strategies focused on the patient such as patient needs assessment, multi-disciplinary discharge planning, discharge instructions, follow-up education, and follow-up assessments.

Patient Focused StrategiesPatient and Family Focused Strategies

Caregiver strategies such as a family caregiver needs assessment, structured education, and skill building.

Patient and Family Focused Strategies

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • and older
  • English and Spanish speaking
  • Preadmission location: community dwelling
  • Distance from Hospital: Local and Distant (rural) included
  • Cognitive impairment, dementia allowed
  • Technology Literacy: Flexible from high to low
  • EPIC readmission risk score over 12
  • Discharged home

You may not qualify if:

  • Admitted from skilled nursing facility
  • Discharged to skilled nursing facility
  • Left Against Medical Advice (AMA)
  • Planned readmission
  • Died during index admission
  • Caregiver unwilling to participate
  • Adults 18 and older
  • English and Spanish speaking
  • Providing tangible support to patient
  • Distance from Hospital: Local and Distant (rural) included
  • Only Mild Cognitive Impairment allowed
  • Able to be trained in Video Visit Technology
  • Available to support post-discharge
  • Has a greater than a mild cognitive impairment (\< 12 on MCA)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Davie Medical Center

Bermuda Run, North Carolina, 27006, United States

RECRUITING

High Point Medical Center

High Point, North Carolina, 27262, United States

RECRUITING

Atrium Health Wake Forest Baptist Wilkes Medical Center

North Wilkesboro, North Carolina, 28659, United States

RECRUITING

Atrium Health Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, 27157, United States

RECRUITING

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition DisordersNeurocognitive DisordersMental Disorders

Study Officials

  • Thomas Houston, MD

    Wake Forest University Health Sciences

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 16, 2026

First Posted

June 22, 2026

Study Start

July 22, 2026

Primary Completion (Estimated)

November 1, 2031

Study Completion (Estimated)

November 1, 2031

Last Updated

July 31, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will not share

Locations