Brief Bronchial Suction for Lung Collapse During Uniportal VATS

NCT07660588 | Not Yet Recruiting

• 1 other identifier: SIRIRAJ-SUCTION-UVATS-2026
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn whether a brief suction of the airway going to the surgical lung (bronchus) can help the lung collapse faster and more completely during uniportal video-assisted thoracoscopic surgery (UVATS). This type of surgery is performed through a small incision in the chest, and good lung collapse helps the surgeon see and work safely. The main questions it aims to answer are

1. 1.Does brief bronchial suction improve the quality of lung collapse 1 minute after chest cavity is opened?
2. 2.Does brief bronchial suction help reach satisfactory lung collapse faster?
3. 3.Undergo UVATS under general anesthesia
4. 4.Have a double-lumen breathing tube placed as part of the standard anesthetic care
5. 5.Be randomly assigned to either receive bronchial suction for one minute or receive no bronchial suction
6. 6.Have the surgical team assess the quality of lung collapse at different time points
7. 7.Have blood samples taken for interleukin-6, a marker related to inflammation, once during and once after surgery. These samples are collected through a small tube in a vein that is placed as a standard anesthetic care while the participant is under general anesthesia. No extra puncture is required for blood collection.
8. 8.Have information collected from the routine anesthesia and surgical records such as oxygen levels during surgery, length of surgery and lung-related complications within 7 days after surgery

Conditions

Lung Collapse; One-lung Ventilation; Thoracic Anesthesia; Thoracic Surgery, Video-assisted; Double-lumen Tube; Uniportal Video Assisted Thoracic Surgery (U-VATS); Postoperative Pulmonary Complications

Keywords

uniportal VATS; UVATS; bronchial suction; lung collapse; one-lung ventilation; double-lumen tube; thoracic anesthesia

Outcome Measures

Primary Outcomes (1)

• Quality of lung collapse at 1 minute after pleural opening

  Surgical team to assess quality of lung collapse at 1 minute after pleural opening by using lung collapse score (LCS). The higher the LCS, the better the lung collapse.

  At 1 minute after pleural opening

Secondary Outcomes (8)

• Quality of lung collapse at pleural opening, 5 minutes and 10 minutes after pleural opening

  At pleural opening, and at 5 and 10 minutes after pleural opening

• Time to satisfactory lung collapse

  From pleural opening until the first LCS of 8 or greater, assessed up to 10 minutes after pleural opening

• Requirement for rescue maneuvers for inadequate lung collapse

  From pleural opening until the end of one-lung ventilation during the index surgery up to 6 hours

• Change in interleukin-6 level from baseline to after one-lung ventilation

  At baseline after induction of anesthesia and at 30-60 minutes after completion of one-lung ventilation

• Incidence of intraoperative hypoxemia

  From initiation of one-lung ventilation until resumption of two-lung ventilation during the index surgery up to 6 hours

Study Arms (2)

Bronchial suction

EXPERIMENTAL

Participants will receive bronchial suction through the operative lumen of the double-lumen endotracheal tube

Other: bronchial suction

No bronchial suction

NO INTERVENTION

Participants will undergo one-lung ventilation without bronchial suction

Interventions

bronchial suction OTHER

Bronchial suction will be performed through the operative lumen of the double-lumen endobronchial tube on two occasions: before pleural opening, and immediately after pleural opening. The suction pressure is at -30 cmH2O and each suction period will last for 60 seconds.

Bronchial suction

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 years old
• BMI ≤ 35 kg/m2
• American Society of Anesthesiologists (ASA) physical status I to III
• Scheduled for elective single-port video-assisted thoracoscopic surgery (VATS) at Siriraj Hospital
• Requirement for one-lung ventilation using a double-lumen tube (DLT)
• Surgery performed in the lateral decubitus position
• Ability to provide written informed consent

You may not qualify if:

• Previous thoracic surgery
• Known or suspected severe pleural adhesions based on preoperative imaging or clinical history
• Tracheobronchial anatomical abnormalities
• Pulmonary bullae identified on chest radiography or computed tomography, or a history of recurrent pneumothorax
• Forced vital capacity (FVC) \< 50% of predicted
• Pregnancy

Sponsors & Collaborators

• Mahidol University: lead

Study Sites (1)

Siriraj Hospital, Mahidol University

Bangkok, 10700, Thailand

Location

Related Publications (19)

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• Quan X, Yi J, Huang Y, Zhang X, Shen L, Li S. Bronchial suction does not facilitate lung collapse when using a double-lumen tube during video-assisted thoracoscopic surgery: a randomized controlled trial. J Thorac Dis. 2017 Dec;9(12):5244-5248. doi: 10.21037/jtd.2017.11.63.

  PMID: 29312732 BACKGROUND

• Zhang Y, Yan W, Fan Z, Kang X, Tan H, Fu H, Li Z, Chen KN, Chen J. Preemptive one lung ventilation enhances lung collapse during thoracoscopic surgery: A randomized controlled trial. Thorac Cancer. 2019 Jun;10(6):1448-1452. doi: 10.1111/1759-7714.13091. Epub 2019 May 21.

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• Hang L, Ju J, Li Y, He M. The impact of suction duration on lung collapse during one-lung ventilation. Front Surg. 2025 Mar 31;12:1532176. doi: 10.3389/fsurg.2025.1532176. eCollection 2025.

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  BACKGROUND

MeSH Terms

Conditions

Pulmonary Atelectasis

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Study Officials

• Nattaya Raykateeraroj, MD

  Siriraj Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nattaya Raykateeraroj, MD

CONTACT

+66993519963; raykageeraroj@gmail.com

Rattanaporn Tankul, MD

CONTACT

+66897714345; rattanaporn.tan@mahidol.ac.th

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants will be randomly assigned in a 1:1 ratio to either a bronchial suction group or a control group. Outcomes will be compared between the two parallel groups.

Study Record Dates

• First Submitted: June 8, 2026
• First Posted: June 22, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): July 1, 2028
• Study Completion (Estimated): July 1, 2028
• Last Updated: June 22, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)