Factors Associated With Late Extubation in Postoperative Patients in the Surgical Intensive Care Unit

NCT07658456 | Completed

• 1 other identifier: KAFGHIRB 108-006
• Study Type: observational
• Target: 204
• Locations: 1 country
• Sites: 1

Brief Summary

Timely removal of a breathing tube after surgery is an important part of recovery for patients admitted to the intensive care unit (ICU). In some cases, patients may require longer use of mechanical ventilation, which can be associated with longer hospital stays and a higher risk of complications. The purpose of this study is to examine clinical factors that may be associated with delayed removal of breathing tubes in postoperative ICU patients. This study will use information that has already been routinely collected during standard medical care, such as patient characteristics, breathing-related measurements, fluid balance, and laboratory test results. This is a retrospective observational study and does not involve any additional treatments, procedures, or changes to routine clinical care. By analyzing these existing data, the study aims to improve understanding of factors related to extubation timing and support future efforts to enhance postoperative ICU care.

Conditions

Delayed Extubation; Postoperative Intensive Care; Mechanical Ventilation Weaning

Keywords

Delayed extubation; Surgical intensive care unit; Mechanical ventilation; Weaning; Machine learning; Postoperative care; Rapid shallow breathing index; serum calcium; cumulative fluid balance; weaning predictors

Outcome Measures

Primary Outcomes (1)

• Delayed Extubation

  Delayed extubation is defined as removal of the endotracheal tube more than 24 hours after initiation of invasive mechanical ventilation during postoperative intensive care unit admission.

  Within 24 hours to 30 days after initiation of invasive mechanical ventilation

Secondary Outcomes (2)

• Hospital Length of Stay

  From hospital admission through hospital discharge, up to 30 days

• Duration of Mechanical Ventilation

  From initiation of invasive mechanical ventilation to extubation, up to 30 days

Study Arms (2)

Early Extubation Group

This cohort includes postoperative intensive care unit patients who were extubated within 24 hours after initiation of invasive mechanical ventilation. No interventions were assigned as part of this study. Clinical data were analyzed retrospectively.

Other: No Intervention - Retrospective Observational Study

Delayed Extubation Group

This cohort includes postoperative intensive care unit patients who were extubated more than 24 hours after initiation of invasive mechanical ventilation. No interventions were assigned as part of this study. Clinical data were analyzed retrospectively.

Other: No Intervention - Retrospective Observational Study

Interventions

No Intervention - Retrospective Observational Study OTHER

No intervention was administered or assigned in this study. This is a retrospective observational study based on secondary analysis of existing clinical data collected during routine clinical care. No changes to patient management, treatment decisions, or standard care were made as part of this study.

Delayed Extubation Group; Early Extubation Group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult postoperative patients admitted to the surgical intensive care unit who required invasive mechanical ventilation as part of routine postoperative care. This retrospective observational study analyzes existing clinical data collected during standard medical practice. No additional interventions, procedures, or changes to patient management were involved.

You may qualify if:

• Postoperative patients admitted to the surgical intensive care unit.
• Patients who required invasive mechanical ventilation after surgery.
• Patients with documented intubation and extubation events during the ICU stay.
• Patients with available routine clinical data, including demographic information, respiratory parameters, and laboratory results.

You may not qualify if:

• Patients without documented extubation information.
• Patients admitted to non-surgical intensive care units.
• Patients with incomplete or missing key clinical data required for analysis.
• Patients who did not receive invasive mechanical ventilation.

Sponsors & Collaborators

• Kaohsiung Armed Forces General Hospital: lead

Study Sites (1)

Kaohsiung Armed Forces General Hospital

Kaohsiung City, 永康區, 802, Taiwan

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 20, 2026
• First Posted: June 22, 2026
• Study Start: April 1, 2019
• Primary Completion: November 30, 2019
• Study Completion: December 31, 2019
• Last Updated: June 22, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)