MCG for Non-Obstructive Myocardial Ischemia

NCT07657546 | Recruiting

• 1 other identifier: MCG-CFR
• Study Type: observational
• Target: 3,786
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this prospective study is to identify Non-Obstructive Myocardial Ischemia of patients who have acute chest pain using Magnetocardiography.

Conditions

Myocardial Ischemia

Keywords

Ischemia with No Obstructive Coronary Arteries

Outcome Measures

Primary Outcomes (1)

• Efficacy of MCG for the detection of Non-Obstructive Myocardial Ischemia

  Establishing an algorithm model of MCG in identifying Non-Obstructive Myocardial Ischemia, the efficacy of the model was assessed by sensitivity, specificity

  from the date of enrollment until the date of discharge, up to 30 days]

Interventions

Magnetocardiography DEVICE

Assessing the performance of magnetocardiography device for detecting non-obstructive myocardial ischemia using ultrasound coronary flow reserve (CFR) as the reference standard.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patient who suffers from cardiogenic chest pain suspected with Non-Obstructive Myocardial Ischemia

You may qualify if:

• Age 18 years or older;
• Patients with symptoms of myocardial ischemia such as angina pectoris, who have CAG showing \<70% stenosis at the most severe site or CTA showing non-severe stenosis
• Signed informed consent.

You may not qualify if:

• Patients with absolute or relative contraindications to CFR-loaded myocardial perfusion, including acute myocardial infarction within 48 hours, significant left main coronary artery stenosis, bronchial asthma, and adenosine injection allergy;
• Patients with Non-ischemic dilated cardiomyopathy, or hypertrophic cardiomyopathy, or moderate or severe valvular disease;
• Patients with Hemodynamic instability (systolic blood pressure\<90 mmHg, or who requires vasoactive drugs), or patients with tachyarrhythmia,
• #degree atrioventricular block and above that have not returned to normal;
• Patients who have severe renal abnormality with eGFR \<30 ml/min, or patients who are on dialysis;
• Patients with malignant tumors with predicted survival of less than 1 year;
• Pregnant or breastfeeding women;
• Patients who are unable to enter the MCG device, who are unable to perform MCG examination due to interference from metal implants or other reasons, or who are deemed by the investigators to be unsuitable for enrollment.

Sponsors & Collaborators

• Qilu Hospital of Shandong University: lead

Study Sites (1)

Qliu Hospital of Shandong University

Jinan, Shandong, 250012, China

RECRUITING

MeSH Terms

Conditions

Myocardial Ischemia

Interventions

Magnetocardiography

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis; Magnetometry; Investigative Techniques

Study Officials

• Yuguo Chen, Professor

  Qliu Hospital of Shandong University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jiaojiao Pang, Doctor

CONTACT

0086-0531-82165398; jiaojiaopang@126.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 14, 2026
• First Posted: June 18, 2026
• Study Start: April 15, 2025
• Primary Completion: June 30, 2026
• Study Completion (Estimated): August 30, 2026
• Last Updated: June 24, 2026

Record last verified: 2026-06

Locations

CN (1)