Impact of IMA Occlusion on Anastomotic Leakage

NCT07656974 | Completed

• 1 other identifier: 2025-98
• Study Type: observational
• Target: 123
• Locations: 1 country
• Sites: 1

Brief Summary

Rectal cancer is primarily treated with surgery, including low anterior resection or ultra-low anterior resection depending on tumor characteristics. Anastomotic leakage is one of the most serious postoperative complications and is associated with increased morbidity and mortality. Established risk factors include male sex, preoperative radiotherapy, low anastomosis, advanced age, comorbidities, and vascular disease. Atherosclerosis may contribute to anastomotic leakage by reducing blood flow and impairing tissue perfusion at the anastomotic site. The inferior mesenteric artery (IMA), a major source of blood supply to the colorectal region, may be affected by atherosclerotic narrowing or occlusion, potentially increasing the risk of postoperative leakage. The aim of this study is to assess the degree of IMA occlusion using routine preoperative contrast-enhanced computed tomography (CT) scans obtained for rectal cancer staging and to investigate its association with anastomotic leakage after rectal cancer surgery. Identification of patients with severe IMA occlusion may help guide the selective use of protective stomas to reduce the risk of this complication.

Conditions

Rectal Cancer Surgery; Anastomotic Leak Rectum; Inferior Mesenteric Artery

Keywords

Rectal cancer surgery; Anastomotic leakage; Inferior mesenteric artery occlusion

Outcome Measures

Primary Outcomes (1)

• The diameter of the inferior mesenteric artery

  The effect of the diameter of the inferior mesenteric artery on the leak rate was measured double-blindly by preoperative computed tomography.

  Preoperative

Study Arms (2)

Group 1

Patients who underwent surgery for rectal cancer and have anastomotic leakage.

Group 2

Patients who underwent surgery for rectal cancer and did not have anastomotic leakage.

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients who have undergone low/ultra-low anterior resection due to rectal cancer.

You may qualify if:

• ICD C20 Patients diagnosed with malignant neoplasm of the rectum
• Patients who have undergone laparoscopic or open surgery with low anterior resection or ultra low anterior resection due to rectal cancer

You may not qualify if:

• Patients with a history of abdominal aorta surgery/grafting
• Patients diagnosed with vascular, autoimmune, or rheumatological diseases.

Sponsors & Collaborators

• Istanbul Saglik Bilimleri University: lead

Study Sites (1)

Basaksehir Cam and Sakura City Hospital

Istanbul, 34480, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Anastomotic Leak

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Yiğit Düzköylü, Assoc. Prof.

  Basaksehir Cam ve Sakura State Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: June 16, 2026
• First Posted: June 18, 2026
• Study Start: May 1, 2025
• Primary Completion: February 1, 2026
• Study Completion: May 1, 2026
• Last Updated: June 18, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)