Foot Intensive Rehabilitation With Perturbation Based Training in Ankle Sprain Patients

NCT07655973 | Completed

• 1 other identifier: UOL/IREB/25/15/03/10
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

To determine the foot-intensive rehabilitation with and without perturbation-based training on pain reduction, range of motion improvement, balance enhancement, and functional instability in patients recovering from ankle sprains NULL HYPOTHESIS There will be no significant difference in the effectiveness of foot-intensive rehabilitation with perturbation-based training compared to foot-intensive rehabilitation alone in reducing pain, improving range of motion, enhancing balance, or reducing functional instability among patients recovering from ankle sprains. ALTERNATE HYPOTHESIS There will be a significant difference in pain reduction, range of motion improvement, balance enhancement, and reduction in functional instability between patients undergoing foot- intensive rehabilitation with perturbation-based training compared to those undergoing foot-intensive rehabilitation. Study Design: It will be a Randomized Clinical Trial Study Population: Ankle Sprain Both groups will undergo the assigned interventions for the duration of 6 weeks under the supervision of trained physical therapists or healthcare professionals. The interventions will aim to address pain reduction, range of motion improvement, balance enhancement, and reduction in functional instability among participants recovering from ankle sprains.

Conditions

Ankle Sprain

Keywords

Foot Perturbation; Foot Intensive Rehabilitation; Ankle Sprain

Outcome Measures

Primary Outcomes (4)

• Numeric pain rate scale (NPRS)

  Patient level of pain will be assessed using this scale. This scale ranges from 0 to 10. 0 indicates "no pain" and 10 indicates "worst pain" (Riley et al., 2019)

  6 weeks (Baseline, 3rd week, 6th week)

• Range of Motion (ROM) Measurement

  Goniometer: To measure dorsiflexion, plantarflexion, inversion, and eversion of the ankle joint(Rome \& Cowieson, 1996).

  6 weeks (Baseline, 3rd week, 6th week)

• Balance Assessment:

  Star Excursion Balance Test (SEBT): Measures reach distances in multiple directions to assess dynamic balance and reach symmetry.(Coughlan et al., 2012)

  6 weeks (Baseline, 3rd week, 6th week)

• Functional Instability Measurement

  Cumberland Ankle Instability Tool (CAIT): A questionnaire to assess the severity of functional ankle instability.(ALEXANDRE et al., 2024)

  6 weeks (Baseline, 3rd week, 6th week)

Study Arms (2)

Foot-Intensive Rehabilitation

ACTIVE COMPARATOR

Foot-Intensive Rehabilitation: Participants in Group A will undergo a structured rehabilitation program focused on addressing ankle sprains and improving foot-specific impairments

Other: Foot-Intensive Rehabilitation

Foot-Intensive Rehabilitation + Perturbation-Based Training

EXPERIMENTAL

In addition to the foot-intensive rehabilitation program, participants will undergo perturbation-based training sessions

Other: Foot-Intensive Rehabilitation + Perturbation-Based Training

Interventions

Foot-Intensive Rehabilitation OTHER

Foot-Intensive Rehabilitation This program will typically include: * Therapeutic Exercises: Range of motion exercises, strengthening exercises for foot and ankle muscles, proprioceptive training, and flexibility exercises tailored to individual needs. * Manual Therapy: Hands-on techniques performed by a physical therapist or trained personnel to address soft tissue restrictions, joint mobilization, and mayofascial release. * Modalities: Use of modalities like ice, heat, ultrasound, or electrical stimulation for pain relief and enhancing tissue healing. * Functional Training: Specific drills and activities mimicking daily tasks or sports- related movements to improve functional capacity.

Foot-Intensive Rehabilitation

Foot-Intensive Rehabilitation + Perturbation-Based Training OTHER

In addition to the foot-intensive rehabilitation program, participants in experimental group will undergo perturbation-based training sessions: * Balance Challenges: Engaging in exercises on unstable surfaces (e.g., balance boards, foam pads) or using devices inducing controlled instability to challenge balance and neuro- muscular control. * Dynamic Movements: Performing controlled perturbations or sudden movements to elicit adaptive responses and improve reactive balance strategies. * Progression: Gradual progression of difficulty and complexity in perturbation-based exercises based on individual tolerance and improvement.

Foot-Intensive Rehabilitation + Perturbation-Based Training

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Gender: male /female
• Participants aged 18 to 35 years old.
• Diagnosis of an ankle sprain (within 4 weeks of injury).
• No prior history of severe ankle fractures or surgeries(Hoch et al., 2023)

You may not qualify if:

• Presence of severe or complex ankle fractures requiring surgical intervention.
• Conditions other than ankle sprain like neuropathy that affect balance or cutaneous sensation.
• Neurological disorders impacting balance or proprioception.
• Pregnancy or planning to become pregnant during the study period(Hoch et al., 2023)

Sponsors & Collaborators

• University of Lahore: lead

Study Sites (1)

Pakistan Sports Board

Lahore, Punjab Province, 54000, Pakistan

Location

MeSH Terms

Conditions

Ankle Injuries

Condition Hierarchy (Ancestors)

Leg Injuries; Wounds and Injuries

Study Officials

• Sana Akram, MSOMPT

  University of Lahore

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 13, 2026
• First Posted: June 18, 2026
• Study Start: December 27, 2025
• Primary Completion: March 12, 2026
• Study Completion: April 27, 2026
• Last Updated: June 30, 2026

Record last verified: 2025-12

Locations

PA (1)