ERAS in Total Knee Arthroplasty: a Randomized Controlled Trial
ERAS
Effectiveness of Enhanced Recovery After Surgery (ERAS) Protocols in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Tria
2 other identifiers
interventional
120
1 country
1
Brief Summary
Total knee arthroplasty(TKA) is the most commonly performed procedure for advanced knee osteoarthritis. Enhanced recovery after surgery (ERAS) protocols are primarily implemented to reduce perioperative stress and improve surgical and functional outcomes. Evidence of the implementation of ERAS protocols in low to middle-income countries like Pakistan is limited. This study aims to evaluate the effectiveness of ERAS protocols in TKA patients. A prospective randomized controlled trial study was conducted within our institute from July 2025 to January 2026, in which a total of 239 patients who underwent primary bilateral TKA, of which 121 patients received conventional treatment and protocols, and a study group with 120 participants were managed according to the ERAS protocol. Patients were in the 50-70 years age bracket, and had an American Society of Anesthesiologists grade I-III. The protocol included preoperative physiotherapy, reduced fasting time, multimodal anesthesia, perioperative tranexamic acid, early ambulation and early oral intake. Postoperative outcomes included time to oral intake, postoperative nausea and vomiting, time to mobilization, length of hospital stay, range of motion and Hospital for Special Surgery score.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started May 2025
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 13, 2025
CompletedFirst Submitted
Initial submission to the registry
May 31, 2026
CompletedFirst Posted
Study publicly available on registry
June 18, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2026
CompletedJune 18, 2026
June 1, 2026
1.1 years
May 31, 2026
June 12, 2026
Conditions
Outcome Measures
Primary Outcomes (2)
TIME TO ORAL INTAKE
DURATION AFTER WHICH NPO WAS BROKEN
Baseline
Length of hospital stay
STAY IN THE HOSPITAL AFTER THE INTERVENTION
through study completion, an average of 1 year
Study Arms (2)
control group
NO INTERVENTIONthe group will receive conventional treatment protocol
study group
EXPERIMENTALeras protocol implementation in this group
Interventions
Eligibility Criteria
You may qualify if:
- ASA grade of 1-3 BMI was restricted to less than 30 kg/m²
You may not qualify if:
- ASA grade of IV or higher uncontrolled comorbidities not consenting to the protocol
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Liaquat National Hospital
Karachi, Sindh, 74200, Pakistan
Related Publications (1)
Wei B, Tang C, Li X, Lin R, Han L, Zheng S, Xu Y, Yao Q, Wang L. Enhanced recovery after surgery protocols in total knee arthroplasty via midvastus approach: a randomized controlled trial. BMC Musculoskelet Disord. 2021 Oct 8;22(1):856. doi: 10.1186/s12891-021-04731-6.
PMID: 34625057RESULT
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- DOCTOR
Study Record Dates
First Submitted
May 31, 2026
First Posted
June 18, 2026
Study Start
May 13, 2025
Primary Completion
July 1, 2026
Study Completion
July 1, 2026
Last Updated
June 18, 2026
Record last verified: 2026-06
Data Sharing
- IPD Sharing
- Will not share