Predicting Risk of Progression of Early to Late AMD in the Aging Eye Through Imaging and Multimodal Evaluation
PRIME
1 other identifier
observational
1,500
1 country
2
Brief Summary
The purpose of this research study is to evaluate a new screening procedure for the early detection and monitoring of AMD in community settings and community hospital settings, to identify associated risk factors, and develop personalized monitoring strategies for at-risk individuals throughout the 5 years follow up period, which will allow us to establish prevalence, natural history of progression of early AMD in the community.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2025
Typical duration for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 18, 2025
CompletedFirst Submitted
Initial submission to the registry
June 11, 2026
CompletedFirst Posted
Study publicly available on registry
June 17, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 31, 2029
June 17, 2026
June 1, 2026
3.8 years
June 11, 2026
June 11, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
To establish the natural history of AMD in Asian elderly and to identify clinical multimodal imaging, genetic, and metabolomic predictors of progression.
Progression is defined as the change from early signs of AMD to advanced AMD.
3 years
Eligibility Criteria
This study will aim for 1500 participants aged ≥ 55 years from SingHealth Community Outreach Programme, other community-based screening initiatives and Outram Community Hospital (OCH).
You may qualify if:
- Adults aged 55 years or older
- No severe systemic illnesses that prevent study participation
- Willing and able to undergo protocol-required procedures for both eyes
- Willing and able to provide written informed consent
You may not qualify if:
- Systemic disorders that preclude reliable clinical examination or multimodal imaging
- Poor compliance or severe mental illness that hinders participation
- Persons who are unable to give informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Singapore National Eye Centrelead
- Singapore Health Servicescollaborator
Study Sites (2)
Outram Community Hospital
Singapore, Singapore
Singapore National Eye Centre/ Singapore Eye Research Institute
Singapore, Singapore
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- ECOLOGIC OR COMMUNITY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
June 11, 2026
First Posted
June 17, 2026
Study Start
October 18, 2025
Primary Completion (Estimated)
July 31, 2029
Study Completion (Estimated)
July 31, 2029
Last Updated
June 17, 2026
Record last verified: 2026-06