Pistacho and Sleep Quality

NCT07651605 | Completed

• 1 other identifier: CBFM-NOV19
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to evaluate the effect of pistachio (Pistacia vera L.) consumption on plasma melatonin, antioxidant capacity, and circadian rhythms in overweight young adults. The main question it aims to answer are:

• Can the consumption of pistachios, specifically their content of compounds like phyto-melatonin, effectively regulate the human biological clock and circadian rhythms?

Conditions

Circadian Rhythm

Keywords

Chrononutrition; circadian clock; sleep; pistachio

Outcome Measures

Primary Outcomes (7)

• Body composition analysis

  Body composition analysis (BCA, including fat mass \[FM\] and fat-free mass \[FFM\], in kg and %) was performed with a seca mBCA 514/515 medical Body Composition Analyzer (Allers Hamburg, Germany). The measurements were conducted in accordance with the guidelines of the International Society for the Advancement of Kinanthropometry (ISAK).

  Baseline, 2 weeks, 4 weeks

• Waist circumference

  Waist circumference (WC, in cm) was measured using an ergonomic SECA 201 measuring tape.

  Baseline, 2 weeks, 4 weeks

• Plasma melatonin

  Plasma obtained from the same samples of biochemicals determinations. Plasma melatonin levels were measured before and after the intervention using a commercial plasma melatonin kit.

  Baseline, 2 weeks, 4 weeks

• Circadian locomotor activity

  A temperature sensor on the wirst, an activity and body position sensor was placed on the participant's arm and a luxometer was worn on the neck with a pendant over the clothing.

  Through study completion during 28-days.

• Questionnaire of activity during the day

  Horne and Östberg morning- evening test. Visual Analog Score with a cumulative score scale

  Baseline, 2 weeks, 4 weeks

• Physical activity questionnaire (IPAQ)

  Measured with the scale MET-minutes per week" (o MET-min/week)

  Baseline, 2 weeks, 4 weeks

• Pittsburgh Sleep Quality Index (PSQI)

  Cumulative score scale by Gobal PSQI score

  Baseline, 2 weeks, 4 weeks

Secondary Outcomes (3)

• Concentration of metabolic and lipid parameters

  Baseline, 2 weeks, 4 weeks

• Plasma antioxidant activity by FRAP method

  Baseline, 2 weeks, 4 weeks

• Plasma antioxidant activity by ORAC assay.

  Baseline, 2 weeks, 4 weeks

Study Arms (1)

Pistacho consumption

EXPERIMENTAL

Participants consumed 28 g (equivalent to 5.6 mg of phytomelatonin) of pistachios each day, specifically 40 pistachios with shells, 1 hour to 30 minutes before bedtime.

Other: Pistacho supplementation

Interventions

Pistacho supplementation OTHER

Participants consumed 28 g (equivalent to 5.6 mg of phyto-melatonin) of pistachios each day, specifically 40 pistachios with shells, 1 hour to 30 minutes before bedtime

Pistacho consumption

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• No diagnosed diseases
• Not regularly taking medications that affect melatonin synthesis or body regulation.

You may not qualify if:

• Smokers
• Pregnant women
• Individuals with night shifts, those following special diets or taking weight loss supplements
• People who had undergone recent surgical procedures or significant weight loss in two months before the study.
• Those taking sleep medications.
• Individuals who had made trans meridian trips within 1 month of the evaluation,
• Individuals with allergies, intolerances, or aversions to nuts/pistachios
• Participants who voluntarily withdrew from the study
• Participants who tested positive for COVID-19 during the intervention
• Participants who experienced adverse effects.

Sponsors & Collaborators

• Universidad Autonoma de Queretaro: lead

Study Sites (1)

Universidad Autónoma de Querétaro

Querétaro City, Querétaro, 76000, Mexico

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Full-time research professor.

Model Details: A 28-day, uncontrolled, base-final intervention study

Study Record Dates

• First Submitted: June 1, 2026
• First Posted: June 16, 2026
• Study Start: September 13, 2021
• Primary Completion: September 26, 2021
• Study Completion: November 1, 2021
• Last Updated: June 16, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

ME (1)