Improve Muscle Weakness in Patient With COPD

NCT07649850 | Not Yet Recruiting DMC

• 1 other identifier: COPD
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

This randomized controlled trial investigated the effects of combining aerobic exercise with blood flow restriction (BFR) training in patients with emphysematous chronic obstructive pulmonary disease (COPD). The study aimed to determine whether adding BFR to aerobic exercise could enhance muscle strength and functional capacity compared with conventional training alone. The findings demonstrated that aerobic exercise combined with BFR significantly improved lower-limb muscle strength, exercise tolerance, and functional performance in patients with emphysematous COPD. These results suggest that BFR-assisted aerobic training may serve as an effective and safe rehabilitation strategy to improve physical function and quality of life in this population.

Conditions

Emphysema or COPD

Keywords

emphysematous COPD; lood flow restriction (BFR); aerobic exercise

Outcome Measures

Primary Outcomes (1)

• muscle strength

  quadriceps strength by isokinetic: Quadriceps strength will be measured using an isokinetic dynamometer at an angular velocity of 60°/s. Participants will perform three to five maximal concentric knee extension efforts after familiarization. Peak torque (Nm) will be recorded, and the highest value will be used for statistical analysis

  8 weeks

Secondary Outcomes (1)

• function capacity

  8 weeks

Study Arms (2)

experimental group

EXPERIMENTAL

aerobic exercise with blood flow restriction (BFR) training Procedure: Aerobic Exercise Training Device: Blood Flow Restriction Cuff

Other: Aerobic Exercise Combined with Blood Flow Restriction

control group

EXPERIMENTAL

aerobic exercise

Other: Aerobic exercise

Interventions

Aerobic Exercise Combined with Blood Flow Restriction OTHER

Aerobic exercise combined with blood flow restriction (BFR) is a rehabilitation technique in which patients perform low- to moderate-intensity aerobic exercise, such as treadmill or cycling training, while a specialized cuff is applied around the proximal part of the limb to partially restrict blood flow. This method aims to enhance muscle strength and functional performance using lower exercise intensity, making it suitable for patients with limited exercise tolerance, such as individuals with COPD.

experimental group

Aerobic exercise OTHER

The control group performed conventional aerobic exercise training at low to moderate intensity without the application of blood flow restriction. The program included activities such as treadmill walking or cycling to improve cardiovascular endurance, functional capacity, and overall physical fitness in patients with COPD.

control group

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients diagnosed with emphysematous chronic obstructive pulmonary disease (COPD).
• Clinically stable COPD patients with no acute exacerbation within the previous 4-6 weeks.
• Mild to moderate disease severity according to GOLD criteria.
• Ability to participate safely in aerobic exercise training.
• Medically stable and cleared by a physician for pulmonary rehabilitation.
• Ability to understand and follow study instructions.

You may not qualify if:

• Acute COPD exacerbation or respiratory infection during the study period.
• Severe cardiovascular diseases (e.g., unstable angina, uncontrolled hypertension, recent myocardial infarction).
• Peripheral vascular disease or contraindications to blood flow restriction (BFR) training.
• Severe musculoskeletal, neurological, or orthopedic disorders limiting exercise performance.
• Cognitive impairment affecting cooperation or informed consent.
• Participation in another structured rehabilitation program during the study period.
• Severe hypoxemia requiring continuous oxygen therapy during exercise.
• History of deep vein thrombosis or clotting disorders.

Sponsors & Collaborators

• Al-Zaytoonah University of Jordan: lead

MeSH Terms

Conditions

Emphysema; Pulmonary Disease, Chronic Obstructive

Interventions

Exercise

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

hanan mohamed

CONTACT

+962775661825; h.hosny@zuj.edu.jo

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor hanan hosny M Battesha

Study Record Dates

• First Submitted: May 14, 2026
• First Posted: June 16, 2026
• Study Start: June 10, 2026
• Primary Completion (Estimated): August 15, 2026
• Study Completion (Estimated): August 30, 2026
• Last Updated: June 16, 2026

Record last verified: 2026-06