Maxillary Canine Retraction Using Stainless Steel and Titanium-molybdenum Alloy Wires in TAD-supported Segmental Mechanics

NCT07645417 | Enrolling By Invitation DMC

• 1 other identifier: BMU/2025/17099
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this randomized clinical study is to compare the effectiveness of stainless steel (SS) and titanium-molybdenum alloy (TMA) wires for maxillary canine retraction using TAD-supported segmental mechanics. The main question it aims to answer is: Which wire material, stainless steel or titanium-molybdenum alloy, provides better outcomes in maxillary canine retraction when used with TAD-supported segmental mechanics? Researchers will compare SS reverse-closing loops with TMA reverse-closing loops to evaluate differences in the rate of canine retraction and canine angulation changes during orthodontic space closure. Participants will:

• Receive mini-implants/TADs on both sides of the maxillary arch.
• Receive a stainless steel reverse-closing loop on one side and a TMA reverse-closing loop on the contralateral side.
• Receive the same standardized force of 150 g on both sides.
• Visit the clinic every 4 weeks for a total duration of 4 months.
• Undergo OPG radiographs before retraction and after the 4-month study period to assess canine angulation.

Conditions

Retraction of Maxillary Canine

Keywords

Stainless steel wire, TMA wire, reverse closing loop, TAD, maxillary canine retraction, segmental mechanics, orthodontic anchorage, canine angulation

Outcome Measures

Primary Outcomes (1)

• Comparison of the rate of maxillary canine retraction using stainless steel and TMA reverse-closing loops in TAD-supported segmental mechanics over 4 months.

  The rate of maxillary canine retraction will be compared using stainless steel and TMA reverse-closing loops in TAD-supported segmental mechanics.

  4 months

Study Arms (2)

A titanium-molybdenum alloy reverse closing loop

ACTIVE COMPARATOR

A titanium-molybdenum alloy reverse-closing loop will be placed on one side of the maxillary arch and activated with 150 g force for canine retraction.

Procedure: A titanium-molybdenum alloy reverse-closing loop; Procedure: A stainless steel reverse closing loop

A stainless steel reverse closing loop

ACTIVE COMPARATOR

A stainless steel reverse-closing loop will be placed on the contralateral side of the maxillary arch and activated with the same 150 g force to retract the canine.

Procedure: A titanium-molybdenum alloy reverse-closing loop; Procedure: A stainless steel reverse closing loop

Interventions

A stainless steel reverse closing loop PROCEDURE

A titanium-molybdenum alloy reverse-closing loop will be placed on one side of the maxillary arch, and a stainless steel reverse-closing loop will be placed on the contralateral side of the maxillary arch and activated with the same 150 g force for canine retraction.

A stainless steel reverse closing loop; A titanium-molybdenum alloy reverse closing loop

A titanium-molybdenum alloy reverse-closing loop PROCEDURE

A titanium-molybdenum alloy reverse-closing loop will be placed on one side of the maxillary arch, and a stainless steel reverse-closing loop will be placed on the contralateral side of the maxillary arch and activated with a 150 g force to retract the canine.

A stainless steel reverse closing loop; A titanium-molybdenum alloy reverse closing loop

Eligibility Criteria

• Age: 15 Months - 35 Months
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Participants aged 15 to 35 years.
• Both male and female participants.
• Patients with all permanent teeth present, excluding third molars.
• Patients requiring extraction of both maxillary first premolars
• Patients with Class I or Class II molar relationship requiring maximum anchorage.
• Patients already undergoing fixed orthodontic treatment with a 0.018-inch Roth preadjusted appliance system.
• Maxillary canines aligned, symmetrical, and upright before the study.
• Patients in the leveling and alignment stage before canine retraction.

You may not qualify if:

• Missing or absent upper premolars.
• Previous orthodontic, orthognathic or reconstructive treatment.
• Systemic disease contraindicating dental implant placement.
• Use of systemic drugs or presence of systemic illness.
• Compromised periodontal condition.
• Use of anti-inflammatory therapy.
• Smokers.
• Pregnant female participants.

Sponsors & Collaborators

• Tanzila Rafique: lead

Study Sites (1)

Bangladesh Medical University (BMU), Dhaka,1000

Dhaka, 1000, Bangladesh

Location

Study Officials

• Mahmood Sajedeen, BDS,FCPS

  Bangladesh Medical UNivbersity (BMU), Dhaka-1000

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Rafique

Model Details: Split-mouth randomized clinical study

Study Record Dates

• First Submitted: June 9, 2026
• First Posted: June 12, 2026
• Study Start: July 1, 2025
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: June 12, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

BA (1)