Mitochondrial Energy Metabolism in Burns
Mito Burn
The Role of the Mitochondrian in the Metabolic Stress Response to Burn Trauma
1 other identifier
observational
125
1 country
1
Brief Summary
The goal of this observational study is to assess the impact of burn injury on cellular energetics in patients that have been admitted to the burn center at Arkansas Children's Hospital for burn care and require one or more procedures to clean, debride, and repair burn wounds will be eligible to participate in this study. During the study, we will collect the following information:
- General background information such as date of birth, height, weight, and other basic information.
- Medical information, such as: basic medical information, details of burn injury, vital signs on the day of surgery, medicines you take during your stay, and some clinical tests.
- Blood, urine, and tissue during surgeries you have during your stay.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Apr 2023
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 20, 2023
CompletedFirst Submitted
Initial submission to the registry
August 10, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2026
CompletedFirst Posted
Study publicly available on registry
June 11, 2026
CompletedJune 11, 2026
June 1, 2026
3.1 years
August 10, 2023
June 9, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Blood Bioenergetics
Peripheral Blood Mononuclear Cell (PBMC) respiration
Through study completion, an average of 1 year
Secondary Outcomes (1)
Blood metabolics signatures
Through study completion, an average of 1 year
Eligibility Criteria
Up to 125 patients (2 years to 80 years old) will be enrolled in this study. We will recruit both males and females requiring hospital admission to the ACH burn unit for burn care.
You may qualify if:
- Male or Female
- Ages 2 years to 80 years
- Requiring hospital admission for burn care
- All races
- All ethnicities
You may not qualify if:
- Age \< 2 years
- Under 10 kg in body mass
- Age \> 80 years
- Active pregnancy
- Unable to provide informed consent and no legal authorized representative present
- Patient is considered moribund at the time of admission by the treating physician.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Arkansas Children's Hospital
Little Rock, Arkansas, 72202, United States
Biospecimen
Blood will be collected to assess mitochondrial function in PBMC's as well as the levels of various metabolites, catechomlamines, cytokines and hormones. Blood samples may be stored for further metabolomic/lipidomic/proteomic analyses. If a urinary catheter is placed for surgery, a urine sample (up to 100 ml) may be collected to assess catecholamine and metabolite levels. During surgical procedures, we will collect any tissue removed from burn wounds as part of your surgery. This may include skin, adipose tissue and muscle.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Craig Porter, PhD
Arkansas Children's Research Institute
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 10, 2023
First Posted
June 11, 2026
Study Start
April 20, 2023
Primary Completion
June 1, 2026
Study Completion
June 1, 2026
Last Updated
June 11, 2026
Record last verified: 2026-06