Evaluation of the Role of Early Second Look TURBT in Management of High Risk Non Muscle Invasive Bladder Cancer

NCT07642102 | Completed

• 1 other identifier: FMASU MS 311/2025
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

The aim is to evaluate the intraoperative, postoperative and pathologic findings of early second look TURBT and the factors affecting these findings to assess the value of early second TURBT in the management of high risk NMIBC.

Conditions

Bladder (Urothelial, Transitional Cell) Cancer Superficial (Non-Invasive); Transurethral Resection of Bladder Tumor

Outcome Measures

Primary Outcomes (1)

• presence of pathologically positive tumor

  6 weeks

Study Arms (1)

patients with non muscle invasive bladder cancer after transurethral resection of bladder tumor

Procedure: early second look transurethral resection of bladder tumor

Interventions

early second look transurethral resection of bladder tumor PROCEDURE

endoscopic early second look transurethral resection of bladder tumor after initial complete resection transurethral resection of non muscle invasive bladder tumor

patients with non muscle invasive bladder cancer after transurethral resection of bladder tumor

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients who underwent initial complete transurethral resection of bladder tumor with high risk non muscle invasive bladder cancer, recruited from the urology outpatient clinic, Urology department, Ain shams University.

You may qualify if:

• patients underwent initial complete resection TURBT with high risk non muscle invasive bladder cancer including: High grade T1 Any carcinoma in situ Any recurrent high grade Ta High grade Ta tumor size is more than 3 cm Any BCG failure in high grade patient Any variant histology Lymphovascular invasion High grade prostatic urethral involvement

You may not qualify if:

• \- Low risk non muscle invasive bladder cancer
• intermediate risk non muscle invasive bladder cancer
• muscle invasive bladder cancer
• metastatic bladder cancer (positive lymph nodes or distant metastasis )
• absent muscle layer in the initial TURBT biopsies
• incomplete resection initial TURBT

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain shams university

Cairo, Cairo Governorate, Egypt

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 7, 2026
• First Posted: June 11, 2026
• Study Start: May 2, 2025
• Primary Completion: October 30, 2025
• Study Completion: December 22, 2025
• Last Updated: June 11, 2026

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will share

Locations

EG (1)