Lung and Heart Function Across Decades of Life in Health

NCT07641413 | Recruiting

• 1 other identifier: UCSF IRB#24-41051
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The main objective of this study is to develop baseline "normal" reference values of both lung and heart function for healthy adults within the age range relevant to the United States Veteran population who served in the Southwest Asia theater of military operations. This study will involve performing key components of the Department of Veterans Affairs the Airborne Hazards and Open Burn Pit Center of Excellence (AHOBPCE) and a VA network of Post-Deployment Cardiopulmonary Evaluation Network (PDCEN) Core Clinical Evaluation in asymptomatic unexposed healthy controls without known lung or heart disease to serve as a "normal" control comparator group for veterans evaluated by PDCEN.

Conditions

Pollution Related Respiratory Disorder; Pollution; Exposure; Dyspnea; Cardiopulmonary

Keywords

Cardiopulmonary function; Pulmonary function testing; Forced oscillometry testing; Echocardiography; Cardiopulmonary exercise testing; Computed tomography imaging

Outcome Measures

Primary Outcomes (3)

• Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

  Pulmonary Function Testing: The purpose of this test is to determine the participant's lungs' capacity.

  2 years

• Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

  Cardiopulmonary Exercise Testing: The purpose of this test is to determine the participant's lung and heart capacity during maximum exercise.

  2 years

• Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

  Echocardiogram: The purpose of this test is to determine how well the subject's heart is functioning and identify causes of cardiac-related symptoms.

  2 years

Secondary Outcomes (5)

• Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

  2 years

• Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

  2 years

• Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

  2 years

• Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

  2 years

• Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

  2 years

Interventions

Healthy control OTHER

Observational study with no intervention

Eligibility Criteria

• Age: 24 Years - 68 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy "normal" adults within the age range relevant to the United States Veteran population who served in the Southwest Asia theater of military operations.

You may qualify if:

• Age 24-68
• No respiratory complaints (defined as modified Medical Research Council score = 0)
• No use of respiratory medications

You may not qualify if:

• Non-English speaking
• Pregnancy
• BMI\>35 Kg/m2
• Tobacco smoking within prior year
• Lifetime tobacco smoking of \>5 pack-years
• Current inhaled cannabis use (any modality) \>2x weekly
• Prior inhaled cannabis uses exceeding 2x weekly within the prior year
• Illicit drug use (other than cannabis)
• No prior or current major organ disease, including but not limited to:
• Neuromuscular weakness
• History of malignancy (other than non-melanoma skin cancer)-- HIV/AIDS
• Autoimmune disease
• Solid-organ or hematopoietic stem cell transplant
• Cardiovascular disease (other than mild HTN; \< 140/90; controlled on 2 or less medications)
• Poorly-controlled HTN (SBP\>140 or DBP\>90 or use of more than 2 anti-hypertensive medications)

Sponsors & Collaborators

• University of California, San Francisco: lead
• US Department of Veterans Affairs: collaborator

Study Sites (1)

University of California San Francisco

San Francisco, California, 94143, United States

RECRUITING

Related Publications (2)

• Zeng S, Nishihama M, Weldemichael L, Lozier H, Gold WM, Arjomandi M. Effect of twice daily inhaled albuterol on cardiopulmonary exercise outcomes, dynamic hyperinflation, and symptoms in secondhand tobacco-exposed persons with preserved spirometry and air trapping: a randomized controlled trial. BMC Pulm Med. 2024 Jan 20;24(1):44. doi: 10.1186/s12890-023-02808-7.

  PMID: 38245665 BACKGROUND

• Zeng S, Dunn M, Gold WM, Kizer JR, Arjomandi M. Remote exposure to secondhand tobacco smoke is associated with lower exercise capacity through effects on oxygen pulse, a proxy of cardiac stroke volume. BMJ Open Respir Res. 2022 May;9(1):e001217. doi: 10.1136/bmjresp-2022-001217.

  PMID: 35551073 BACKGROUND

MeSH Terms

Conditions

Dyspnea

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Mehrdad Arjomandi, MD

  University of California, San Francisco

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mehrdad Arjomandi, MD

CONTACT

415-221-4810; mehrdad.arjomandi@ucsf.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 1, 2026
• First Posted: June 11, 2026
• Study Start: August 1, 2024
• Primary Completion (Estimated): December 31, 2030
• Study Completion (Estimated): December 31, 2030
• Last Updated: June 11, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)