Dentin Hypersensitivity in Orthodontic Patients: Triple-Blinded, Randomized Trial of Three Desensitizing Agents.
Dentin Hypersensitivity: Triple-Blinded, Multicenter Randomized Trial of Three Desensitizing Dentifrices vs Non-Desensitizing Control
1 other identifier
interventional
200
0 countries
N/A
Brief Summary
The effect of desensitizing agents will be studied on dentin hypersensitivity in orthodontic patients.it is a randomized controlled trial. three experimental groups and one placebo group.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jul 2026
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 7, 2026
CompletedFirst Posted
Study publicly available on registry
June 11, 2026
CompletedStudy Start
First participant enrolled
July 15, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 15, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 15, 2026
June 11, 2026
June 1, 2026
3 months
June 7, 2026
June 7, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
REDUCTION IN DENTIN HYPERSENSITIVITY
Change in dentin hypersensitivity scores from baseline to 8 weeks using the Visual Analog Scale (VAS) and Schiff Cold Air Sensitivity Scale.
8 WEEKS
Study Arms (4)
TEST TOOTHPASTE GROUP 1
EXPERIMENTALParticipants in this arm will use the test toothpaste twice daily for 8 weeks.
TEST TOOTH PASTE GROUP 2
ACTIVE COMPARATORParticipants in this arm will use the test toothpaste twice daily for 8 weeks.
TEST TOOTH PASTE GROUP 3
ACTIVE COMPARATORParticipants in this arm will use the test toothpaste twice daily for 8 weeks.
TEST TOOTH PASTE GROUP 4
PLACEBO COMPARATORParticipants in this arm will use the test toothpaste twice daily for 8 weeks.
Interventions
TOOTH PASTE A NON-DESENSITIZING CONTROL
Eligibility Criteria
You may qualify if:
- Orthodontic patients aged 18-40 years.
- Presence of mild to moderate dentin hypersensitivity (VAS ≥ 4).
- Willingness to comply with a 12-week follow-up period.
- No active periodontal disease or untreated caries.
- Not pregnant or breastfeeding.
- No history of allergy to desensitizing agents
You may not qualify if:
- o Patients with systemic conditions affecting oral health (e.g., diabetes, immunocompromised).
- Patients using medications that affect tooth sensitivity (e.g., anti-inflammatory drugs).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Interventions
Study Officials
- STUDY CHAIR
Dr. Zubair Hassan Awaisi, FCPS
PRINCIPAL NID MULTAN
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr Fatima Khalid
Study Record Dates
First Submitted
June 7, 2026
First Posted
June 11, 2026
Study Start
July 15, 2026
Primary Completion (Estimated)
October 15, 2026
Study Completion (Estimated)
December 15, 2026
Last Updated
June 11, 2026
Record last verified: 2026-06