Patterns of Cardiac Arrhythmia in Patients With Chronic Kidney Disease

NCT07640919 | Not Yet Recruiting

• 1 other identifier: Soh-Med-26-5-5MS
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiovascular diseases remain the primary leading cause of death in patients on maintenance hemodialysis accounting for nearly 41% of deaths. Chronic kidney disease is associated with an excess of acquired arrhythmia of multiple types, and atrial fibrillation in particular. Sudden cardiac death is also more common in chronic kidney disease and accounts for around one- quarter of deaths in dialysis patients. The aim of the study is to evaluate the incidence, describe the patterns of cardiac arrhythmia and to determine the factors predisposing to cardiac arrhythmia in patients with chronic kidney disease with or without hemodialysis.

Conditions

Chronic Kidney Disease With and Without Hemodialysis

Keywords

chronic kidney disease (CKD); cardiac arrhythmia; atrial fibrillation (AF)

Outcome Measures

Primary Outcomes (1)

• Detection of changes (already exsited) in heart rate (measured in beats/ minutes) and corrected QT interval (measured in milliseconds) from normal limits in patients with chronic kidney disease.

  Twelve-lead ECG is performed and all ECGs are reviewed for the following parameters: * heart rate (measured by beats/minutes) normal limit: 60 - 100 b/m * corrected QT interval (measured in milliseconds) normal limit: 330 - 440 ms in males and 330 - 450 in female

  Health survey distributed during 4 months to determine how many patients with chronic kidney disease have cardiac arrhythmia in hemodialysis unit and outpatient nephrology clinic at sohag university hospitals

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with chronic kidney disease at hemodialysis unit and outpatient nephrology clinic at Sohag university hospitals

You may qualify if:

• Patients with CKD (no intercurrent illness or uremic symptoms, and not hospitalized in the previous 3 months) with renal replacement therapy on maintenance HD (three times/week for at least three months) or without renal replacement therapy, aged 18 or above.

You may not qualify if:

• Patients aged \<18 years old.
• Patients on drugs that are known to prolong the QT interval (e.g., antibiotics as clarithromycin, antifungal as fluconazole, antiarrhythmics as amiodarone, antipsychotic as chlorpromazine)
• Patients with structural heart diseases (e.g.,significant valvular lesions )
• Patients with impaired left ventricular systolic functions (defined as EF\< 50%
• Patients with malignancy, severe infection or sepsis.
• Patients with major bleeding.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag university hospitals

Sohag, ElKholy, 82714, Egypt

Location

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Arrhythmias, Cardiac; Atrial Fibrillation

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Heart Diseases; Cardiovascular Diseases

Study Officials

• Emad Ahmad Mohamad, Associate professor

  Faculty of medicine, Sohag university, Internal medicine department

  STUDY DIRECTOR

Central Study Contacts

Magi Mogahed Mounir, Resident doctor

CONTACT

00201276347105; magi.mogahed@med.sohag.edu.eg

Noher Mohamad Abass, Associate professor

CONTACT

00201224921932; nohermohamed3581@gmail.com

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident doctor at internal medicine department

Study Record Dates

• First Submitted: June 2, 2026
• First Posted: June 11, 2026
• Study Start (Estimated): July 20, 2026
• Primary Completion (Estimated): December 20, 2026
• Study Completion (Estimated): January 20, 2027
• Last Updated: June 11, 2026

Record last verified: 2026-06

Locations

EG (1)