Impact of Del Nido Versus Blood Cardioplegia on Myocardial Viability Assessed With Magnetic Resonance Imaging
1 other identifier
interventional
60
1 country
2
Brief Summary
Myocardial protection during surgical myocardial revascularization is crucial for reducing perioperative myocardial injury and improving postoperative outcomes. Blood cardioplegia represents the standard method in many centers, while del Nido cardioplegia, originally developed for the pediatric population, is increasingly being used in adult patients as well.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jun 2026
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 15, 2026
CompletedStudy Start
First participant enrolled
June 1, 2026
CompletedFirst Posted
Study publicly available on registry
June 9, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
June 1, 2027
June 9, 2026
June 1, 2026
1 year
April 15, 2026
June 7, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Myocardial Viability Assessed by Magnetic Resonance Imaging
Myocardial Viability Assessed by Magnetic Resonance Imaging
Patients will undergo the initial cardiac MRI scan before surgery. The follow-up MRI will be scheduled approximately 4 weeks after surgical revascularization.
Secondary Outcomes (1)
Major Adverse Cardiac and Cerebrovascular Events
MACCE will be adjudicated at 30 days and 6 months.
Study Arms (2)
Del Nido cardioplegia
ACTIVE COMPARATORCABG patients receiving Del Nido cardioplegia as the myocardial protection strategy
Blood cardioplegia
ACTIVE COMPARATORCABG patients receiving blood cardioplegia as the myocardial protection strategy
Interventions
CABG patients receiving Del Nido cardioplegia as the myocardial protection strategy
Patients will receive Blood Cardioplegia Solution for myocardial protection
Eligibility Criteria
You may not qualify if:
- Left ventricular ejection fraction \<30%
- Associated cardiac procedures
- Off-pump coronary artery bypass grafting
- Contraindications for MRI
- Inability to provide consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
University Hospital Center Zagreb
Zagreb, 10000, Croatia
University Hospital Center Zagreb
Zagreb, 10000, Croatia
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Hrvoje Gasparovic
Clinical Hospital Centre Zagreb
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Head, Department of Cardiac Surgery
Study Record Dates
First Submitted
April 15, 2026
First Posted
June 9, 2026
Study Start
June 1, 2026
Primary Completion (Estimated)
June 1, 2027
Study Completion (Estimated)
June 1, 2027
Last Updated
June 9, 2026
Record last verified: 2026-06