Interaction Between Head/Neck Position and C-MAC Blade Geometry on Videolaryngoscopic Intubation in Morbidly Obese Patients: A Randomized Controlled Trial

NCT07636746 | Active Not Recruiting DMC

• 1 other identifier: FMASU R81/2026
• Study Type: interventional
• Target: 140
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to explore the effect of head/neck position (sniffing vs ramped) and C-MAC blade geometry (MAC vs D-blade) on intubation in morbidly obese patients. The patients will be randomized into 4 groups:

1. 1.S MAC: Sniffing + MAC blade.
2. 2.R MAC: Ramped + MAC blade.
3. 3.S D-blade: Sniffing + D-blade.
4. 4.R D-blade: Ramped + D-blade.

Conditions

Morbid Obesity

Outcome Measures

Primary Outcomes (1)

• Intubation time (seconds), from blade insertion to confirmed placement via capnography.

  Intubation time (seconds), from blade insertion to confirmed placement via capnography.

  seconds

Study Arms (4)

S MAC: Sniffing + MAC blade.

ACTIVE COMPARATOR

the patient will be positioned in sniffing position and MAC blade will be used in intubation

Device: Sniffing position and using MAC blade.

Ramped position and using MAC blade.

ACTIVE COMPARATOR

the patient will be positioned in Ramped position and MAC blade will be used in intubation

Device: Ramped position and MAC Blade

S D-blade: Sniffing + D-blade.

ACTIVE COMPARATOR

the patient will be positioned in sniffing position and D-blade will be used in intubation

Device: videolaryngoscopy

R D-blade: Ramped + D-blade.

ACTIVE COMPARATOR

the patient will be positioned in Ramped position and D-blade willbe used in intubation

Device: videolaryngosopy

Interventions

Ramped position and MAC Blade DEVICE

MAC blade will be used in intubating patient in ramped postion

Ramped position and using MAC blade.

videolaryngoscopy DEVICE

D-blade will be used in intubating patient in sniffing position

S D-blade: Sniffing + D-blade.

videolaryngosopy DEVICE

D-blade will be used in intubating patient in Ramped position

R D-blade: Ramped + D-blade.

Sniffing position and using MAC blade. DEVICE

Machintosch blade will be used in intubating patient in sniffing position

S MAC: Sniffing + MAC blade.

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18-70 years.
• BMI ≥ 40 kg/m².
• ASA physical status III - IV.
• Elective surgery requiring intubation.
• Informed consent obtained.

You may not qualify if:

• Anticipated difficult airway unrelated to obesity.
• Cervical spine pathology.
• Pregnancy.
• Emergency surgery.
• High aspiration risk.
• OSA requiring CPAP \>15 cmH₂O.
• Need for awake intubation.

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain Shams University

Cairo, Egypt, 00202, Egypt

Location

MeSH Terms

Conditions

Obesity, Morbid

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• fagr fathy abdo, Medical Doctorate

  Ain Shams University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 4, 2026
• First Posted: June 9, 2026
• Study Start: April 17, 2026
• Primary Completion (Estimated): September 20, 2026
• Study Completion (Estimated): November 1, 2026
• Last Updated: June 9, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share

Locations

EG (1)