Long-term DBBM Dimensional Changes in Sinus Grafting

NCT07635472 | Completed DMC

• 1 other identifier: CER 2025-288
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate graft volumetric changes and stability up to 12 years after lateral sinus floor elevation with deproteinized bovine bone mineral (DBBM) as a filling material.

Conditions

Deproteinized Bovine Bone Mineral Graft Dimensional Changes

Keywords

Bone loss, deproteinized bovine bone mineral, computer-assisted image processing, dental implant, sinus floor augmentation, sinus pneumatization.

Outcome Measures

Primary Outcomes (1)

• bovine bone mineral graft dimensional changes

  To evaluate radiologically using CBCT deproteinized bovine bone mineral graft dimensional changes in region of lateral sinus lift.

  12 years

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who underwent lateral external sinus lift at the Faculty of dentistry at Saint Joseph University of Beirut

You may qualify if:

• Patients who underwent lateral sinus floor elevation with natural bovine bone as filling material after 2011 at the Faculty of Dentistry, Saint Joseph University of Beirut.
• At least 18 years old at baseline
• Systemically healthy
• Patients who sign a new informed consent.
• Smokers (≥ 10 cigarettes/ day) and non-smokers (\< 10 cigarettes/ day)

You may not qualify if:

• Patients who did not take a CBCT within 1 year after the initial surgery.
• Presence of inflammatory lesions at the surgical site (eg, sinusitis as assessed by CBCT).
• History of radiation therapy in the head/neck region.
• Use of bisphosphonates.

Sponsors & Collaborators

• Saint-Joseph University: lead

Study Sites (1)

Saint Joseph University - Faculty of Dental Medicine

Beirut, Lebanon

Location

Related Publications (1)

• 1. Couso-Queiruga E, Stuhr S, Tattan M, Chambrone L, Avila-Ortiz G. Post-extraction dimensional changes: A systematic review and meta-analysis. 2. Pjetursson BE, Heimisdottir K. Dental implants - are they better than natural teeth? Eur J Oral Sci. 2018 Oct;126(S1):81-7. 3. Menassa G, Kassir AR, Landi L, Naaman NBA, Chakar C. Implant placement with sinus floor elevation via the lateral approach using only absorbable collagen sponge: 12-month post-loading radiographical outcomes and implant survival rate. Oral Maxillofac Surg. 2021 Jun;25(2):231-6. 4. Danesh-Sani SA, Engebretson SP, Janal MN. Histomorphometric results of different grafting materials and effect of healing time on bone maturation after sinus floor augmentation: a systematic review and meta-analysis. J Periodontal Res. 2017 Jun;52(3):301-12. 5. Tatum H. Maxillary and sinus implant reconstructions. Dent Clin North Am. 1986 Apr;30(2):207-29. 6. Wiltfang J, Schultze-Mosgau S, Nkenke E, Thorwarth M, Neukam FW, Schlegel KA. Onlay augmentation versus sinuslift procedure in the treatment of the severely resorbed maxilla: a 5-year comparative longitudinal study. Int J Oral Maxillofac Surg. 2005 Dec;34(8):885-9. 7. Binger T, Hell B. Resorption of microsurgically vascularized bone grafts after augmentation of the mandible. J Cranio-Maxillo-fac Surg Off Publ Eur Assoc Cranio-Maxillo-fac Surg. 1999 Apr;27(2):82-5. 8. Jensen OT, Shulman LB, Block MS, Iacono VJ. Report of the Sinus Consensus Conference of 1996. Int J Oral Maxillofac Implants. 1998;13 Suppl:11-45. 9. Stern A, Green J. Sinus Lift Procedures: An Overview of Current Techniques. Dent Clin North Am. 2012 Jan;56(1):219-33. 10. Zijderveld SA, Schulten EAJM, Aartman IHA, ten Bruggenkate CM. Long-term changes in graft height after maxillary sinus floor elevation with different grafting materials: radiographic evaluation with a minimum follow-up of 4.5 years. Clin Oral Implants Res. 2009 Jul;20(7):691-700. 11. Schmitt C, Karasholi T, Lutz R, Wiltfang J

  BACKGROUND

MeSH Terms

Conditions

Bone Diseases, Metabolic

Condition Hierarchy (Ancestors)

Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 24, 2026
• First Posted: June 9, 2026
• Study Start: June 1, 2025
• Primary Completion: April 6, 2026
• Study Completion: May 20, 2026
• Last Updated: June 9, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

LE (1)