Combined Aerobic and Resistance Exercise in Peritoneal Dialysis Patients

NCT07634211 | Completed

• 2 other identifiers: PD-EX-2022Ethics Approval 9/XVI-2022
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this randomized controlled trial was to learn whether a combined aerobic and resistance exercise program could improve physical function and muscle health in people receiving peritoneal dialysis. Researchers compared an exercise group with a control group to evaluate the effects of regular exercise. The main questions the study aimed to answer were:

• Can regular exercise improve physical performance and muscle strength in people receiving peritoneal dialysis?
• Can regular exercise improve body composition and blood markers related to muscle health? Before the exercise program, participants completed a one-month training period to learn the exercises and practice them safely. Participants in the exercise group:
• Performed combined aerobic and resistance exercises for 8 weeks
• Completed assessments before and after the exercise program Participants in the control group:
• Continued their usual care
• Completed assessments before and after the study period

Conditions

Peritoneal Dialysis

Keywords

Peritoneal Dialysis; exercise; Physical Performance; Muscle Strength; Body Composition

Outcome Measures

Primary Outcomes (4)

• Physical Performance

  Changes in physical performance assessed using the 6-minute walk test after 8 weeks of combined aerobic and resistance exercise.

  Baseline and after 8 weeks of intervention

• Changes in right handgrip strength

  Changes in right handgrip strength measured in kilograms after 8 weeks of combined aerobic and resistance exercise.

  Baseline and after 8 weeks of intervention

• Changes in left handgrip strength

  Changes in left handgrip strength measured in kilograms after 8 weeks of combined aerobic and resistance exercise.

  Baseline and after 8 weeks of intervention

• Changes in leg strength

  Changes in lower extremity muscle strength measured using a leg and back dynamometer after 8 weeks of combined aerobic and resistance exercise.

  Baseline and after 8 weeks of intervention

Secondary Outcomes (7)

• Changes in flexibility

  Baseline and after 8 weeks of intervention

• Changes in Fat Tissue Index (FTI)

  Baseline and after 8 weeks of intervention

• Changes in Lean Tissue Index (LTI)

  Baseline and after 8 weeks of intervention

• Changes in serum IGF-1 levels

  Baseline and after 8 weeks of intervention

• Changes in serum ACTH levels

  Baseline and after 8 weeks of intervention

Other Outcomes (3)

• Changes in biceps skinfold thickness

  Baseline and after 8 weeks of intervention

• Changes in triceps skinfold thickness

  Baseline and after 8 weeks of intervention

• Changes in abdominal skinfold thickness

  Baseline and after 8 weeks of intervention

Study Arms (2)

exercise group

EXPERIMENTAL

Participants performed a combined aerobic and resistance exercise program for 8 weeks.

Behavioral: Combined Aerobic and Resistance Exercise

control group

NO INTERVENTION

Participants continued their usual care during the study period without a structured exercise program.

Interventions

Combined Aerobic and Resistance Exercise BEHAVIORAL

Participants performed a structured combined aerobic and resistance exercise program for 8 weeks. Before the intervention period, participants completed a one-month training and adaptation phase to learn the exercises and ensure safe participation. The exercise program aimed to improve physical performance, muscle strength, and muscle health in people receiving peritoneal dialysis.

exercise group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 years or older
• Receiving peritoneal dialysis for at least 6 months
• Ability to sit and stand independently

You may not qualify if:

• Myocardial infarction within the previous 6 months
• History of cardiac surgery
• Uncontrolled hypertension
• Pericardial or pleural effusion
• Aortic stenosis
• Active lower extremity amputation, prosthesis, or fracture
• History of osteoporotic fractures
• Regular participation in sports or structured exercise
• Advanced cognitive impairment

Sponsors & Collaborators

• Dilek GİBYELİ GENEK: lead
• Muğla Sıtkı Koçman University: collaborator

Study Sites (1)

Mugla Sitki Kocman University Faculty of Medicine, Mugla Training and Research Hospital

Muğla, Muğla, 48000, Turkey (Türkiye)

Location

Related Publications (3)

• Lu Y, Wang Y, Lu Q. Effects of Exercise on Muscle Fitness in Dialysis Patients: A Systematic Review and Meta-Analysis. Am J Nephrol. 2019;50(4):291-302. doi: 10.1159/000502635. Epub 2019 Sep 3.

  PMID: 31480056 BACKGROUND

• Heiwe S, Jacobson SH. Exercise training for adults with chronic kidney disease. Cochrane Database Syst Rev. 2011 Oct 5;2011(10):CD003236. doi: 10.1002/14651858.CD003236.pub2.

  PMID: 21975737 BACKGROUND

• Uchiyama K, Washida N, Morimoto K, Muraoka K, Kasai T, Yamaki K, Miyashita K, Wakino S, Itoh H. Home-based Aerobic Exercise and Resistance Training in Peritoneal Dialysis Patients: A Randomized Controlled Trial. Sci Rep. 2019 Feb 22;9(1):2632. doi: 10.1038/s41598-019-39074-9.

  PMID: 30796338 BACKGROUND

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor of Nephrology

Model Details: Participants were assigned to either an exercise group or a control group and followed in parallel throughout the study period

Study Record Dates

• First Submitted: May 11, 2026
• First Posted: June 8, 2026
• Study Start: July 1, 2022
• Primary Completion: September 30, 2022
• Study Completion: September 30, 2022
• Last Updated: June 8, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)