NCT07633327

Brief Summary

The proposed clinical research project aims to explore the functional dynamics of innate immune cells in patients. The protocol includes collecting samples from episodes of inflammatory disease, from which fluid will be extracted. The sampling procedure will be carried out non-invasively for the patient. Following collection, the fluid and cells will be separated. The cytokine profile of the fluid will be analyzed using ELISA and flow cytometry to detect inflammatory cytokines in the patient. The isolated cells from the fluid will then be analyzed by flow cytometry and differentially identified based on the physiological state of the patient, as well as to identify the presence of inflammatory markers in these immune cells.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
24mo left

Started Jun 2026

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress2%
Jun 2026May 2028

Study Start

First participant enrolled

June 1, 2026

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

June 3, 2026

Completed
5 days until next milestone

First Posted

Study publicly available on registry

June 8, 2026

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 31, 2027

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

May 31, 2028

Last Updated

June 8, 2026

Status Verified

June 1, 2026

Enrollment Period

12 months

First QC Date

June 3, 2026

Last Update Submit

June 3, 2026

Conditions

Peritoneal Lavage

Outcome Measures

Primary Outcomes (1)

  • Immune cells dynamic

    Number of cells in each immune cell population, characterization of the composition of each population based on cellular subsets,

    At the inclusion

Interventions

Digestive surgeryPROCEDURE

Routine digestive surgery

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All patients indergoing digestive surgery in Nice CHU

You may qualify if:

  • All patients undergoing digestive surgery from 18 to 80 years old.

You may not qualify if:

  • Patients under immunomodulatory treatments

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU de Nice

Nice, Alpes-Maritimes, 06000, France

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Immune cells

MeSH Terms

Interventions

Endoscopy, Digestive System

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Digestive SystemDiagnostic Techniques and ProceduresDiagnosisEndoscopyDiagnostic Techniques, SurgicalDigestive System Surgical ProceduresSurgical Procedures, OperativeMinimally Invasive Surgical Procedures

Central Study Contacts

Zakariya Caillot

CONTACT

0489153825zakariya.caillot@etu.unice.fr

Andrea Chierici

CONTACT

04920325882andreapiero.chierici@gmail.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 3, 2026

First Posted

June 8, 2026

Study Start

June 1, 2026

Primary Completion (Estimated)

May 31, 2027

Study Completion (Estimated)

May 31, 2028

Last Updated

June 8, 2026

Record last verified: 2026-06

Locations

FR(1)