NCT07631481|Completed
Posture, Interface, and Peak Cough Flow
PCF P/I
Body Posture and Interface Effects on Peak Cough Flow in Healthy Adults: A Randomized Crossover Study
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PCF P/I
Body Posture and Interface Effects on Peak Cough Flow in Healthy Adults: A Randomized Crossover Study
Sponsor study identifier
interventional
24
1 country
1
Study Start
May 1, 2024
Actual (reported)Primary Completion
August 31, 2024
Actual (reported)Study Completion
May 21, 2026
Actual (reported)Cough is a key airway protective mechanism requiring coordinated neuromuscular function. Peak cough flow (PCF) is a simple, non-invasive measure widely used to assess cough effectiveness and guide clinical decisions. Current ATS/ERS guidelines recommend measuring PCF in a seated position using a mouthpiece with a nose clip; however, this setup is not always feasible in clinical practice. Some patients cannot maintain posture or ensure an adequate mouthpiece seal, making a facial mask a potential alternative. The influence of body position and interface on PCF measurements remains unclear, with limited evidence from randomized crossover studies. This study aims to evaluate the effects of body position (sitting vs standing) and measurement interface (mouthpiece vs facial mask) on PCF in healthy young adults. In a randomized within-subject crossover design, participants perform PCF measurements under four conditions (Sit-Mask, Stand-Mask, Sit-Mouthpiece, Stand-Mouthpiece) during a single session. The findings will help inform more flexible and standardized PCF assessment procedures in clinical practice.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 21, 2026
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 1, 2024
Actual (reported)August 31, 2024
Actual (reported)May 21, 2026
Actual (reported)May 21, 2026
Actual (reported)June 8, 2026
Actual (reported)Peak cough Flow (PCF)
PCF measurement in L/s
Day 1
Peak cough flow measured in the seated position. The facial mask (V2 Mask™, Hans Rudolph, Inc., Kansas, USA; size fitted to participant) was connected to an ultrasonic spirometer (SpiroScout, Ganshorn) via a PFT filter. Participants performed three tidal breaths followed by a maximal cough, repeated three times.
Peak cough flow measured in the standing position. Same device and procedure as Sit-Mask condition.
Cliniques universitaires Saint-Luc
Brussels, 1180, Belgium
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J; ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J. 2005 Aug;26(2):319-38. doi: 10.1183/09031936.05.00034805. No abstract available.
Brennan M, McDonnell MJ, Duignan N, Gargoum F, Rutherford RM. The use of cough peak flow in the assessment of respiratory function in clinical practice- A narrative literature review. Respir Med. 2022 Mar;193:106740. doi: 10.1016/j.rmed.2022.106740. Epub 2022 Jan 15.
24 participants (actual enrollment reported by the registry).
First Submitted
May 21, 2026
First Posted
June 8, 2026
Study Start
May 1, 2024
Actual (reported)Peak cough flow measured in the seated position. The mouthpiece (Pulmosafe, Lemon Medical GmbH, Hammelburg, Germany) was used with a nose clip and connected to an ultrasonic spirometer (SpiroScout, Ganshorn) via a PFT filter. Participants performed three tidal breaths followed by a maximal cough, repeated three times.
Peak cough flow measured in the standing position. Same device and procedure as Sit-Mouthpiece condition.
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Primary Completion
August 31, 2024
Actual (reported)Study Completion
May 21, 2026
Actual (reported)Last Updated
June 8, 2026
Record last verified: 2026-06
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Source: ClinicalTrials.gov.
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