Democratizing Access to Cleaner Residential Air

NCT07629518 | Not Yet Recruiting

• 2 other identifiers: 25-285-2R34HL173375
• Study Type: interventional
• Target: 66
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this research study is to determine whether the use of in-home air filtration to reduce exposure to air pollution benefits health.

Conditions

Cardiovascular (CV) Risk

Keywords

air pollution; air purifiers; HEPA filtration; cardiovascular risk; biomarkers

Outcome Measures

Primary Outcomes (1)

• Blood pressure

  Periferal blood pressure, seated

  Day 0, 30, 45, and 75

Secondary Outcomes (1)

• IL-1beta

  Day 0, 30, 45, and 75

Study Arms (2)

Active filtration

EXPERIMENTAL

Air purifiers with HEPA filters

Other: Portable air purifiers with HEPA filtration

Sham filtration

SHAM COMPARATOR

Air purifiers lacking HEPA filters

Other: Portable air purifiers without filtration (sham)

Interventions

Portable air purifiers with HEPA filtration OTHER

Portable air purifiers filter air and reduce exposure to air pollutants, in this case, airborne particulate matter

Active filtration

Portable air purifiers without filtration (sham) OTHER

Air purifiers with filters removed (sham)

Sham filtration

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 40 years or older Speaks English, Vietnamese, and/or Chinese Cognitive capacity to respond to questionnaires Lives fulltime at the current address, adjacent (\< 200 meters) to roadways with large traffic volumes Must have one or more risk factors (hypertension or elevated blood pressure, pre-diabetes or diabetes or elevated blood sugar levels, elevated cholesterol levels, body mass index 25 or greater)

You may not qualify if:

• Pregnant Works between the hours of 10 PM and 6 AM Sources of smoke in the living space (such as candles, incense, marijuana, wood stove, fireplace) almost every day/every day.
• Every day exposure to motor vehicle exhaust (from cars, trucks, buses, trains), including heavy street or highway traffic.
• Currently smoking or vaping Others smoking or vaping indoors, in the living space. Within the past 5 years, a diagnosis of heart attack, heart disease, stroke, blood clots or pulmonary embolism, cancer requiring surgery and/or chemo/radiation therapy

Sponsors & Collaborators

• Douglas Brugge: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

MeSH Terms

Interventions

Filtration; salicylhydroxamic acid

Intervention Hierarchy (Ancestors)

Chemistry Techniques, Analytical; Investigative Techniques; Physical Phenomena; Chemical Phenomena

Study Officials

• Doug M Brugge

  UConn Health

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Doug Brugge, PhD

CONTACT

18606748814; brugge@uchc.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor and Chair

Model Details: Double blind, randomized crossover

Study Record Dates

• First Submitted: June 1, 2026
• First Posted: June 5, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): May 1, 2028
• Study Completion (Estimated): May 1, 2029
• Last Updated: June 5, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: June, 2028 onward
• Access Criteria: Other qualified researchers will be sent the database upon submitting a request that indicates a valid analysis for this data