Relationship Between Periodontal Inflammation Severity and Pan-Immune System Inflammation Value

NCT07628803 | Completed

• 1 other identifier: BAİBU-Perio-ZA-01
• Study Type: observational
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

This cross-sectional observational study aims to evaluate the relationship between periodontal inflammation severity and the Pan-Immune-Inflammation Value (PIV) in systemically healthy adults. A total of 160 participants will be recruited from the Department of Periodontology, Faculty of Dentistry, Bolu Abant Izzet Baysal University. Clinical periodontal parameters and Periodontal Inflamed Surface Area (PISA) will be recorded, and their association with PIV calculated from complete blood count parameters will be analyzed.

Conditions

Periodontitis; Periodontal Health; Gingivitis

Keywords

Periodontal Inflamed Surface Area; PISA; Pan-Immune-Inflammation Value; PIV; Systemic Inflammation; Complete Blood Count; Periodontal Disease

Outcome Measures

Primary Outcomes (1)

• Correlation between Periodontal Inflamed Surface Area and Pan-Immune-Inflammation Value

  The correlation between Periodontal Inflamed Surface Area and Pan-Immune-Inflammation Value will be evaluated. Periodontal Inflamed Surface Area will be calculated using periodontal clinical measurements, including probing pocket depth, gingival recession, and bleeding on probing, and will be expressed in square millimeters. Pan-Immune-Inflammation Value will be calculated from complete blood count parameters using the formula: neutrophil count × platelet count × monocyte count / lymphocyte count.Correlation coefficient between Periodontal Inflamed Surface Area and Pan-Immune-Inflammation Value.

  Baseline (single visit)

Secondary Outcomes (5)

• Correlation between Periodontal Inflamed Surface Area and Systemic Immune-Inflammation Index

  Baseline (single visit)

• Correlation between Periodontal Inflamed Surface Area and Systemic Inflammation Response Index

  Baseline (single visit)

• Periodontal Inflamed Surface Area

  Baseline, single visit.

• Systemic Immune-Inflammation Index

  Baseline, single visit.

• Systemic Inflammation Response Index

  Baseline, single visit.

Study Arms (3)

Periodontitis

Systemically healthy individuals diagnosed with Stage III or Stage IV periodontitis according to the 2017 World Workshop Classification of Periodontal and Peri-Implant Diseases and Conditions.

Gingivitis

Systemically healthy individuals with gingival inflammation without clinical attachment loss consistent with periodontitis.

Periodontally Healthy

Systemically healthy individuals with clinically healthy periodontal tissues and no evidence of periodontitis.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Systemically healthy adults aged 18 years and older who present to the Department of Periodontology, Faculty of Dentistry, Bolu Abant Izzet Baysal University, and who are diagnosed as periodontally healthy, having gingivitis, or having Stage III-IV periodontitis according to the 2017 World Workshop Classification of Periodontal and Peri-Implant Diseases and Conditions.

You may qualify if:

• Age 18 years and older
• Systemically healthy individuals
• Complete blood count performed within the previous 3 months
• Diagnosis of periodontal health, gingivitis, or Stage III-IV periodontitis according to the 2017 World Workshop Classification of Periodontal and Peri-Implant Diseases and Conditions
• Willingness to provide written informed consent

You may not qualify if:

• Pregnancy or lactation- History of systemic diseases that may affect periodontal tissues
• Use of antibiotics or anti-inflammatory drugs within the previous 3 months
• Periodontal treatment within the previous 6 months
• Presence of infectious diseases such as HIV, hepatitis B, or tuberculosis

Sponsors & Collaborators

• Abant Izzet Baysal University: lead

Study Sites (1)

Faculty of Dentistry, Bolu Abant İzzet Baysal University, Department of Periodontics

Bolu, Central, 14100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Periodontitis; Gingivitis; Periodontal Diseases

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Infections; Gingival Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assist Prof

Study Record Dates

• First Submitted: May 22, 2026
• First Posted: June 5, 2026
• Study Start: December 15, 2025
• Primary Completion: May 15, 2026
• Study Completion: May 15, 2026
• Last Updated: June 5, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)