Association Between Screening Behaviors and Lung Cancer Spectrum

NCT07626177 | Recruiting

• 1 other identifier: ECTOP-1038
• Study Type: observational
• Target: 5,390
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to describe the clinical epidemiological characteristics and disease spectrum distribution of newly diagnosed primary lung cancer patients in a real-world setting. The main questions it aims to answer are: What is the current status of lung cancer epidemiology, including age, gender, smoking history, and pathological subtype distribution? How do different lung cancer screening behaviors (e.g., overscreening, underscreening, guideline-concordant, and precision screening) influence the capture rate of the "curative time window" (defined as adenocarcinoma in situ (AIS)/minimally invasive adenocarcinoma (MIA) or pure Ground-Glass Nodules (GGNs) stage)? What are the economic costs and cumulative radiation exposure associated with these different screening patterns? Researchers will compare these screening behavior groups to evaluate the efficacy of the "low-age, low-frequency" screening strategy in capturing early-stage lung cancer. Participants will be asked to: Provide their medical history and detailed records of pre-diagnosis lung cancer screening (including CT scan history). Allow researchers to collect and analyze their clinical, pathological, and radiological data from hospital records and medical databases. Complete a questionnaire regarding their screening history and health-related behaviors.

Conditions

Lung Cancer

Outcome Measures

Primary Outcomes (1)

• Epidemiological Characteristics

  Distribution of age, gender, smoking history, and pathological subtypes.

  through study completion, an average of 1 year

Secondary Outcomes (4)

• Curative Time Window Capture Rate

  through study completion, an average of 1 year

• Socioeconomic Indicators

  through study completion, an average of 1 year

• Cumulative Radiation Dose

  through study completion, an average of 1 year

• Screening Efficacy

  through study completion, an average of 1 year

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of patients with pathologically confirmed primary lung cancer who are newly diagnosed within the past year at Fudan University Shanghai Cancer Center and participating multicenter sites. The population includes individuals across various age groups, smoking statuses, and risk profiles, who are capable of providing detailed medical history and pre-diagnosis screening records. Patients with recurrent lung cancer, metastatic disease, or those unable to complete the study questionnaires due to cognitive or mental health conditions are excluded.

You may qualify if:

• Histologically confirmed primary lung cancer within the past year (surgical or biopsy pathology).
• Patients capable of clearly recalling or providing medical and physical examination history prior to diagnosis.

You may not qualify if:

• Recurrent lung cancer or metastatic lung tumors.
• Severe lack of critical clinical data (e.g., inability to provide pathological type or stage).
• Patients with cognitive impairment or severe mental illness who cannot cooperate with the questionnaire.

Sponsors & Collaborators

• Fudan University: lead

Study Sites (1)

Fudan University Cancer Center

Shanghai, Shanghai Municipality, 200032, China

RECRUITING

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Month
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor and Chief of Thoracic Surgery, Fudan University Shanghai Cancer Center

Study Record Dates

• First Submitted: May 18, 2026
• First Posted: June 4, 2026
• Study Start: May 14, 2026
• Primary Completion (Estimated): May 1, 2027
• Study Completion (Estimated): June 1, 2027
• Last Updated: June 4, 2026

Record last verified: 2026-05

Locations

CN (1)