Impact of the Intraoperative Use of Amines in Breast Cancer Surgery on Tumor Recurrence

NCT07624734 | Active Not Recruiting

• 1 other identifier: 2025-11-366
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

Adrenergic receptors (alpha and beta) are expressed on breast cancer cells, and their stimulation has been shown in experimental studies to promote tumor proliferation and metastasis. Conversely, observational data suggest that beta-blockers may have a protective effect on cancer recurrence. During mastectomy, adrenergic agonists such as catecholamines (e.g., ephedrine, phenylephrine, norepinephrine) and other agents (e.g., clonidine) are frequently used intraoperatively to maintain hemodynamic stability, potentially activating these receptors. While some data suggest that perioperative adrenergic stimulation may influence tumor biology, the clinical impact on cancer recurrence remains unclear. This retrospective exploratory study aims to evaluate whether the use of adrenergic agents during anesthesia for mastectomy influences tumor recurrence in breast cancer patients. Approximately 250 patients undergoing mastectomy over a 5-year period will be included. The study will assess the association between intraoperative exposure to adrenergic drugs and oncological outcomes, with the goal of better understanding the potential role of perioperative factors in cancer progression.

Conditions

Cancer Recurrence; Breast Cancer

Keywords

breast cancer recurrence; catecholamines

Outcome Measures

Primary Outcomes (1)

• cancer recurrence

  either local recurrence or metastases

  5 years post-surgery

Study Arms (1)

patients operated for a mastectomy for cancer

Patients undergoing mastectomy for cancer management (including both adult and pediatric patients).

Other: collection of health data from electronic medical records

Interventions

collection of health data from electronic medical records OTHER

collection of demographic data, key medical history, use of beta-blockers prior to surgery, anesthesia-related data (agents used to maintain anesthesia, regional anesthesia in addition to general anesthesia, intraoperative use of amines), postoperative morphine consumption, survival, and cancer recurrence within 5 years post-surgery

patients operated for a mastectomy for cancer

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

all patients operated between 2015 and 2020 for a mastectomy

You may qualify if:

• patients operated for a mastectomy for breast cancer

You may not qualify if:

• other surgeries for breast cancer not being a mastectomy
• mastectomy for other conditions than cancer

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

CHU Montpellier

Montpellier, Hérault, 34000, France

Location

Related Publications (2)

• Bruzzone A, Pinero CP, Castillo LF, Sarappa MG, Rojas P, Lanari C, Luthy IA. Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. Br J Pharmacol. 2008 Oct;155(4):494-504. doi: 10.1038/bjp.2008.278. Epub 2008 Jul 7.

  PMID: 18604234 BACKGROUND

• Perez Pinero C, Bruzzone A, Sarappa MG, Castillo LF, Luthy IA. Involvement of alpha2- and beta2-adrenoceptors on breast cancer cell proliferation and tumour growth regulation. Br J Pharmacol. 2012 May;166(2):721-36. doi: 10.1111/j.1476-5381.2011.01791.x.

  PMID: 22122228 BACKGROUND

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 19, 2026
• First Posted: June 3, 2026
• Study Start: December 1, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): June 1, 2027
• Last Updated: June 3, 2026

Record last verified: 2026-04

Locations

FR (1)