Comparative Effects of Mediterranean and DASH Diet on Hepatic Function

NCT07622680 | Completed

• 1 other identifier: IRB-UOL-FAHS/717/2025
• Study Type: interventional
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

Participants were assigned into three groups Control group recieving general dietary guidelines, Mediterranean diet intervention group DASH dietary intervention group

Conditions

Hep A; NAFLD (Nonalcoholic Fatty Liver Disease)

Keywords

Mediterranean Diet,; DASH diet,; Liver Function Test,; Lipid profile,

Outcome Measures

Primary Outcomes (2)

• Body Mass Index

  Body Mass Index (BMI) was computed by dividing weight in kilograms by the square of height in meters (kg/m2).

  60 days

• Liver Function Test

  The blood test was used to measure the serum concentrations of ALT, AST, and GGT. Following an overnight fast, 10 ml of venous blood was collected from participants both at baseline and post-intervention.

  60 days

Study Arms (3)

Control group

PLACEBO COMPARATOR

Control group (T0): Participants were given dietary guidelines to manage fatty liver disease followed by medications.

Other: Dietary guidelines for fatty liver

Treatment group (T1)

EXPERIMENTAL

Treatment group (T1): Participants were given Mediterranean diet plan for 2 months.

Other: Mediterranean diet

Treatment group (T2)

EXPERIMENTAL

Treatment group (T2): Participant were given DASH diet plan for 2 months.

Other: DASH diet

Interventions

Dietary guidelines for fatty liver OTHER

Dietary guidelines for managing fatty liver disease followed by medication for 2 months.

Control group

Mediterranean diet OTHER

Mediterranean diet plan consists of vegetables, whole grains, and fruit, extra virgin olive oil, nuts, seeds and legumes.

Treatment group (T1)

DASH diet OTHER

DASH diet plan consists of antioxidant foods items i.e. fruits and vegetables lean meat and dairy products (low fat dairy products), nuts, grain.

Treatment group (T2)

Eligibility Criteria

• Age: 25 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults (25-70 years) of both genders with BMI (above 25 kg/m2).
• Fatty liver patients with mild to moderate values of Alanine Transaminase (ALT) level range from mild to moderate (30-100U/L)
• Fatty liver patients having Aspartate Aminotransferase (AST) level range from mild to moderate (200-600 IU/L).
• Fatty liver patients having Gamma-Glutamyl Transferase (GGT level range from mild to moderate(120-300 U/L) were included.

You may not qualify if:

• Lactating and pregnant women were not included.
• Patients who are using any kind of medicine.
• Adults suffering from critical health conditions, including cancer.

Sponsors & Collaborators

• University of Lahore: lead

Study Sites (1)

University of Lahore

Lahore, Pakistan

Location

Related Links

• Related Info

MeSH Terms

Conditions

Non-alcoholic Fatty Liver Disease

Interventions

Nutrition Policy; Diet, Mediterranean; Dietary Approaches To Stop Hypertension

Condition Hierarchy (Ancestors)

Fatty Liver; Liver Diseases; Digestive System Diseases

Intervention Hierarchy (Ancestors)

Health Policy; Public Policy; Social Control Policies; Policy; Health Care Economics and Organizations; Diet, Plant-Based; Diet Therapy; Nutrition Therapy; Therapeutics; Diet; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Head University Institute of Diet and Nutritional Sciences

Study Record Dates

• First Submitted: May 23, 2026
• First Posted: June 3, 2026
• Study Start: November 12, 2025
• Primary Completion: January 17, 2026
• Study Completion: February 20, 2026
• Last Updated: June 3, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)