The Implementation of Genetic Risk for Colorectal Cancer Screening

NCT07621757 | Enrolling By Invitation

• 1 other identifier: IRB2026-0064
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are:

1. 1.How does knowledge of a patient's genetic risk for colorectal cancer affect the uptake of initial screening colonoscopies?
2. 2.How do colonoscopy outcomes compare between genetic risk groups?

Conditions

Colorectal Cancer; Colorectal Adenoma; Colorectal Polyp

Outcome Measures

Primary Outcomes (1)

• Number of scheduled colonoscopies in each genetic risk group

  One year following enrollment

Secondary Outcomes (1)

• Number of polyps and/or adenomas found through colonoscopy in each genetic risk group

  One year following enrollment

Eligibility Criteria

• Age: 45 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Participants enrolled in the Genomic Health Initiative (GHI) at Endeavor Health in Illinois who meet the age requirements for screening colonoscopy and have consented to be recontacted for future non-GHI studies

You may qualify if:

• \- Due for initial screening colonoscopy per current guidelines

You may not qualify if:

• Prior colonoscopy
• Prior personal history of colorectal cancer or inflammatory bowel disease
• Medical contraindications to colonoscopy/sedation

Sponsors & Collaborators

• Endeavor Health: lead

Study Sites (1)

Endeavor Health

Evanston, Illinois, 60201, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Saliva samples will be collected for DNA sequencing

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Vice President and Director, Genomic Translational Research

Study Record Dates

• First Submitted: May 22, 2026
• First Posted: June 2, 2026
• Study Start: June 1, 2026
• Primary Completion (Estimated): January 31, 2027
• Study Completion (Estimated): May 31, 2027
• Last Updated: June 2, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)