Usefulness of a Virtual Response Test as a Predictor of Functional and Cognitive Abilities in Older Adults With Different Degrees of Cognitive Impairment: a Pilot Study (ReactVR)

NCT07620509 | Completed

• 1 other identifier: HEALTHYFIT-UVIGO 2/2026
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

1. 1.BACKGROUND Population aging is one of the most significant trends of the 21st century.In 2020, 21% of the European population was 65 years of age or older, compared to 16% in 2001.Today, 1 in 9 people is over 60, but it is estimated that by 2050, this will be 1 in 5. Therefore, population aging is a phenomenon that can no longer be ignored. In recent decades, the increase in the number of older people is due to the increase in life expectancy. By 2026, the average life expectancy for men is estimated at 77.65 years, and for women, values are projected to reach 85.5 years.
2. 2.HYPOTHESES AND OBJECTIVES H0: Knowing the functional reaction times assessed with virtual reality does not help to understand the integrity of the physical, functional, and cognitive abilities of older adults with cognitive impairment, nor can it predict their risk of falling or their level of cognitive impairment.

Conditions

Alzheimer s Disease; Dementia; Virtual Reality; Virtual Reality Cognitive Training; Reaction Time

Outcome Measures

Primary Outcomes (1)

• Virtual reality reaction time test

  A measurement is taken using the Rezzil reaction time test (measured in milliseconds). This software comprises a collection of training games designed to improve physical and cognitive performance across a wide range of sports within an immersive virtual reality (VR) environment. In microwall mode, a 3x3 grid is presented, and the objective is to respond to a random stimulus projected onto it with a rapid limb movement, making several attempts over 45 seconds. The average reaction time is recorded

  Baseline

Secondary Outcomes (3)

• Level of cognitive impairment assessed using the Global Deterioration Scale (GDS)

  Baseline

• Level of cognitive ability assessed using the Cambridge Cognitive Examination-Revised (CAMCOG-R) test

  Baseline

• Gait functionality measured with the Timed Up and Go Test (TUG test)

  Baseline

Study Arms (1)

Virtual reaction time test Group

EXPERIMENTAL

The intervention will consist of a single session measuring virtual reaction times using Rezill software

Other: Virtual reality reaction time test

Interventions

Virtual reality reaction time test OTHER

A measurement is taken using the Rezzil reaction time test (measured in milliseconds). This software comprises a collection of training games designed to improve physical and cognitive performance across a wide range of sports within an immersive virtual reality environment. In microwall mode, a 3x3 grid is presented, and the objective is to respond to a random stimulus projected onto it with a rapid limb movement, making several attempts over 45 seconds.

Virtual reaction time test Group

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• age ≥65 years
• membership in a patient association with cognitive impairment
• signed informed consent

You may not qualify if:

• cardiovascular, pulmonary or musculoskeletal pathology that limits the evaluation
• inability to understand instructions
• severe sensory impairment, vertigo, epilepsy or uncontrolled psychosis

Sponsors & Collaborators

• University of Vigo: lead
• The Association of Relatives of Alzheimer's Patients and Other Dementias of Galicia (Afaga Alzheimer): collaborator

Study Sites (1)

University of Vigo

Vigo, Pontevedra, 36316, Spain

Location

MeSH Terms

Conditions

Dementia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 26, 2026
• First Posted: June 2, 2026
• Study Start: May 25, 2026
• Primary Completion: May 25, 2026
• Study Completion: May 26, 2026
• Last Updated: June 2, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)