LLM Intervention for Tobacco in Underserved Populations (LIFT-UP)

NCT07620301 | Not Yet Recruiting

• 2 other identifiers: HCI199440U54CA280812
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

This study will test a tailored, multilingual tobacco cessation chatbot called LIFT-UP (LLM Intervention for Tobacco in Underserved Populations), designed to better meet the needs of people living in persistent poverty census tracts. This study will use 1:1 semi-structured interviews to explore social drivers of health impacting TC, as well as digital access and preferences among those living in PPCTs. This qualitative approach enables guided yet flexible exploration of key domains while capturing unanticipated insights relevant to refining the chatbot.

Conditions

Smoking Cessation

Outcome Measures

Primary Outcomes (1)

• System Usability Scale (SUS)

  Usability will be measured using the SUS, a questionnaire assessing the perceived usability of a system, product, website, app, or digital intervention. It consists of ten 5-point Likert items ranging from "Strongly disagree" to "Strongly agree". Scoring follows the standard SUS scoring procedure, for positively worded items, the item score is calculated as response minus 1; for negatively worded items, the item score is calculated as 5 minus the response. The 10 item scores are summed and then multiplied by 2.5 to generate the final SUS score, with higher scores indicating greater perceived usability. Score range: 0-100.

  up to 1 day

Secondary Outcomes (4)

• Usability - Chat Bot Usability Scale (BUS-11)

  up to 1 day

• Acceptability

  up to 1 day

• Digital Working Alliance

  up to 1 day

• Perceived cultural fit

  up to 1 day

Study Arms (1)

Moderated Session

EXPERIMENTAL

Participants will attend a \~80 minute moderated "think-aloud" session via HIPAA compliant videoconferencing platform.

Behavioral: LIFT-UP Chatbot

Interventions

LIFT-UP Chatbot BEHAVIORAL

LIFT-UP Chatbot will be developed, evaluated, and refined using GARDE-Chat, an open-source chatbot authoring platform that has been used to support the development of chatbot-based interventions tested in large pragmatic clinical trials.

Moderated Session

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• + years old
• Use ≥3 cigarettes/day on average
• Motivated to quit in the next 30 days
• Have a computer or tablet with internet access for 1:1 interviews
• Speak English or Spanish
• Home address is in an area characterized by persistent poverty

You may not qualify if:

• None

Sponsors & Collaborators

• University of Utah: lead
• National Cancer Institute (NCI): collaborator
• Huntsman Cancer Institute: collaborator

Study Sites (1)

Huntsman Cancer Institute/ University of Utah

Salt Lake City, Utah, 84102, United States

Location

MeSH Terms

Conditions

Smoking Cessation

Condition Hierarchy (Ancestors)

Health Behavior; Behavior

Study Officials

• Chelsey Schlechter, MPH, PhD

  Huntsman Cancer Institute/ University of Utah

  PRINCIPAL INVESTIGATOR

• Christian Mahony Reategui Rivera, MD, MS

  University of Utah

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Lindsey Potter, MPH, PhD

CONTACT

801-213-6036; Lindsey.Potter@hci.utah.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 26, 2026
• First Posted: June 2, 2026
• Study Start: June 1, 2026
• Primary Completion (Estimated): May 31, 2027
• Study Completion (Estimated): May 31, 2027
• Last Updated: June 3, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)