Care Bundle to Limit External Ventricular Drain Associated iNfections

NCT07619625 | Not Yet Recruiting

• 1 other identifier: 26Anesthesie-Réa
• Study Type: observational
• Target: 248
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of our study is to reduce the incidence of External ventricular drain (EVD)-related infections by implementing a bundle of measures including updated care protocoles and training of residents, nurses and nurses assistants. At Nice University Hospital, we are conducting a retrospective study showing a 22% infection rate associated with EVD. The identified pathogens are mainly transmitted by manual contact. Additionnally, high turnover among paramedical staff and sometimes rapid training may contribute to infection ocurrence. We hypothesize that a significant proportion of patients with EVD develop nosocomial ventriculitis, primarily due to modificable risk factors such as catheter handling and breaches in aseptic technique.

Conditions

Health Care Associated Infection

Outcome Measures

Primary Outcomes (1)

• Occurrence of an infection related to EVDs between the day of insertion and up to 30 daysafterward.

  Number of infections according to the 2017. Altération de la biochimie du LCR. Clinical deterioration of the patient

  From the inclusion up to 30 days

Secondary Outcomes (2)

• Occurrence of a contamination related to EVDs

  From the inclusion up to 30 days.

• Occurrence of a colonisation related to EVDs

  From the inclusion up to 30 days.

Study Arms (1)

EVD-associated infection cohort in CIU and step-down care

Other: Bundle of measures including updated care protocoles and training of residents, nurses and nurses assistants

Interventions

Bundle of measures including updated care protocoles and training of residents, nurses and nurses assistants OTHER

Preventive measures are structured around several key areas : updating the EVD insertion protocol and the EVD care protocol, optimizing dressing changes and scalp cleansing ; ; creation of reminder signage displayed outside the rooms of patients with an EVD outlining key hygiene rules ; implementation of theoretical teaching and simulation sessions for residents and nurses, covering EVD management, infectious complications, their treatment, and prevention ; assessment through a questionnaire on EVD management before implementation of preventive measures and after.

EVD-associated infection cohort in CIU and step-down care

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients admitted to the general intensive care and intermediate care units of Nice University Hospital who underwent EVD placement on site.

You may qualify if:

• Age ≥ 18 years.
• Hospitalized in a general intensive care unit or intermediate care unit at Nice University Hospital.
• Having undergone EVD placement within the institution.

You may not qualify if:

• EVD placed outside the institution with no possibility of follow-up.
• Patient under immediate therapeutic limitation.
• Pre-existing neuromeningeal infection.
• Expression by the patient or by the trusted person of opposition to the processing of the patient's medical data.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

MeSH Terms

Conditions

Cross Infection

Interventions

Nurses

Condition Hierarchy (Ancestors)

Infections; Iatrogenic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Health Personnel; Health Care Facilities Workforce and Services

Central Study Contacts

Julie Borovik

CONTACT

06 98 86 83 50; borovik.j@chu-nice.fr

Pauline Duchemin

CONTACT

0602650248; duchemin.p@chu-nice.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 26, 2026
• First Posted: June 2, 2026
• Study Start: June 1, 2026
• Primary Completion (Estimated): October 1, 2028
• Study Completion (Estimated): December 1, 2028
• Last Updated: June 2, 2026

Record last verified: 2026-05