Right Ventricular Function and Respiratory Acidosis After Cardiac Surgery

NCT07619274 | Not Yet Recruiting

• 1 other identifier: 2027-4604
• Study Type: observational
• Target: 220
• Locations: 1 country
• Sites: 1

Brief Summary

Right heart dysfunction remains a frequent cause of morbidity and mortality after cardiac surgery. Respiratory acidosis, particularly when accompanied by hypoxemia, plays a significant role in right heart failure, primarily by increasing right ventricular afterload through pulmonary vasoconstriction and elevated pulmonary arterial pressures. This phenomenon leads to increased right ventricular workload, causing dilation, decreased contractility, and ultimately right heart failure. The study aims to evaluate the effect of respiratory acidosis on right ventricular function after cardiac surgery.

Conditions

Respiratory Acidosis in ICU Patients; Right Ventricular (RV) Dysfunction; Hemodynamic Changes; Mechanical Ventilation

Outcome Measures

Primary Outcomes (1)

• Right ventricular function per central hemodynamic assessment

  Calculation of different predictor: Cardiac index, PAPi (pulmonary artery pulse pressure over central venous pressure) , RVSWI ((mean pulmonary artery pressure- central venous pressure) X stroke volume index X 0.0136) and RV-CPO

  At intensive care unit admission - within the first 4 hours

Secondary Outcomes (5)

• Intensive care unit length of stay

  Up to 28 days

• Mechanical ventilation duration

  Day 28

• Vasopressor duration

  Day 28

• Acute renal failure

  Day 28

• Mortality

  Day 28

Study Arms (2)

Retrospective cohort

Completed study. Adult patients who underwent cardiac surgery were included if they were admitted to the intensive care unit immediately after surgery, mechanically ventilated in controlled mode, and had an arterial blood gas within the first hour following admission.

Other: Not applicable- observational study

Prospective cohort

Completed study. Adult patient included on open-label randomized study, comparing clinician-chosen initial mechanical ventilation parameters to those recommended by an algorithm immediately after ICU admission.

Other: Not applicable- observational study

Interventions

Not applicable- observational study OTHER

No intervention

Prospective cohort; Retrospective cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients who underwent cardiac surgery mechanically ventilated in controlled mode, and had an arterial blood gas within the first hour following admission.

You may qualify if:

• Previously included and complete study NCT05886413 or NCT06826794

You may not qualify if:

• Absence of one or more of the following hemodynamic measurements: systolic or diastolic pulmonary artery pressure, central venous pressure, cardiac output
• Absence of arterial blood gas on arrival to the intensive care unit

Sponsors & Collaborators

• Laval University: lead

Study Sites (1)

Institut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval

Québec, Quebec, G1V4G5, Canada

Location

Central Study Contacts

Etienne Couture

CONTACT

1-418-656-8711; etienne.couture.3@ulaval.ca

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Co-Investigator

Study Record Dates

• First Submitted: May 8, 2026
• First Posted: June 1, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: June 1, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)