Adapted Physical Activity (APA) Following Hospitalization in Frail Older Adults

NCT07617714 | Not Yet Recruiting

• 1 other identifier: SHAPE
• Study Type: interventional
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

To evaluate the effectiveness of an Adapted Physical Activity (APA) program in improving functional capacity and reducing frailty in older adults following hospital discharge. The aim is to determine whether a structured program of personalized exercises improves mobility, strength, and quality of life compared to standard care.

Conditions

Oncologic Disease

Outcome Measures

Primary Outcomes (1)

• Improvement in overall physical function assessed by changes in the Short Physical Performance Battery (SPPB) score."

  4 months

Study Arms (2)

Adapted Physical Activity Program

OTHER

Other: Adapted Physical Activity Program

routine care

OTHER

Other: routine care

Interventions

Adapted Physical Activity Program OTHER

a 14-week Adapted Physical Activity (APA) program following hospital discharge

Adapted Physical Activity Program

routine care OTHER

Participants in the control group will receive standard post-discharge care, along with general recommendations for physical activity and healthy lifestyle habits

routine care

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• The study is open to individuals aged 65 and older.
• Current diagnosis or recent history of cancer.
• Patients currently undergoing treatment (chemotherapy, immunotherapy, targeted therapy) or in follow-up after recent treatment (≤12 months since completion).
• Functional capacity compatible with participation in an adapted physical activity program, as determined by clinical assessment.
• Recent hospitalization: Patients must have been discharged following a hospital stay.
• Frailty: Presence of a significant level of frailty at hospital discharge.

You may not qualify if:

• Short Physical Performance Battery\> 10: Patients considered "robust" are excluded to maximize the relevance of the intervention.
• Acute unstable medical condition or contraindication to exercise: Any unstabilized acute condition that makes physical activity dangerous (e.g., acute cardiac complication, ongoing severe infection). Recent major medical events (myocardial infarction, major surgery, bone fracture, or major amputation in the past few weeks) will also be excluded.
• Severe chronic conditions incompatible with exercise: Severe progressive diseases that prevent safe exercise, such as severe neuromuscular diseases or advanced organ failure (e.g., end-stage renal failure).
• Short-term life-threatening prognosis: Patients in the terminal phase or with a very limited life expectancy (less than 6 months).
• Total functional dependence or severe motor impairment: Patients who are completely dependent for basic activities (very low Barthel Index, e.g., \<20/100) or who are unable to move even minimally (e.g., unable to walk a few steps or stand, even with assistance).
• Severe cognitive impairment: Severe cognitive impairment (e.g., advanced dementia without the ability to follow simple instructions) that prevents active participation in the program.
• Severe sensory or communication disorders: Significant sensory impairments-such as profound uncompensated blindness or deafness-or any communication barrier (severe aphasia, language barrier) that prevents participation in the program, unless a caregiver (family member or professional) can be present to ensure safety during the exercises.
• Institutionalization of the patient: Individuals who do not live in their usual residence are excluded. The study focuses on older adults returning home, as the institutional setting involves different care.
• Lack of valid informed consent: Any patient who refuses to participate or who cannot provide valid consent (due to lack of legal capacity or understanding) will be excluded.
• Participation in another concurrent program or trial: Simultaneous participation in another physical exercise program or trial.

Sponsors & Collaborators

• Biobizkaia Health Research Institute: lead

Central Study Contacts

Elena Galve, Doctor

CONTACT

944006000; elena.galvecalvo@osakidetza.eus

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 22, 2026
• First Posted: June 1, 2026
• Study Start: June 1, 2026
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: June 2, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share