Effect of Prostatic Urethra and Seminal Vesicle Morphometry on Ejaculation

NCT07614854 | Not Yet Recruiting

• 1 other identifier: KAEK-11/24.12.2025.472
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn whether the size and shape of the prostatic urethra and seminal vesicles - measured on multiparametric prostate MRI (mpMRI) - are related to premature ejaculation (PE) severity in men aged 18-55. The main questions it aims to answer are:

• Do men with premature ejaculation have different prostatic urethral length and angulation compared to men without PE?
• Do men with premature ejaculation have different seminal vesicle dimensions compared to men without PE?
• Do prostatic urethra and seminal vesicle measurements on mpMRI correlate with PE severity scores (PEDT) and ejaculation latency time (IELT)? Researchers will compare men with premature ejaculation to healthy men without ejaculatory complaints to see if specific anatomical features are associated with PE severity. Participants will:
• Undergo a multiparametric prostate MRI that is already scheduled as part of their routine medical care
• Complete validated questionnaires about ejaculation and sexual function (PEDT, PEP, IELT, IIEF-15)
• Provide a blood sample for routine hormone level measurements

Conditions

Premature Ejaculation; Ejaculation

Keywords

Prostatic Urethra; seminal vesicle; morphometry

Outcome Measures

Primary Outcomes (3)

• Correlation Between Prostatic Urethral Length and Premature Ejaculation Severity

  Pearson or Spearman correlation between prostatic urethral length measured on mpMRI (mm) and PEDT score. Higher PEDT score indicates greater PE severity (range 0-20).

  At enrollment (single time point)

• Correlation Between Seminal Vesicle Dimensions and Premature Ejaculation Severity

  Pearson or Spearman correlation between seminal vesicle anterior-posterior length and superior-anterior length measured on mpMRI (mm) and PEDT score. Higher PEDT score indicates greater PE severity (range 0-20).

  At enrollment (single time point)

• Correlation Between Prostatic Urethral Angulation and Intravaginal Ejaculation Latency Time

  Pearson or Spearman correlation between prostatic urethral angulation measured on mpMRI (degrees) and IELT (seconds). Lower IELT indicates greater PE severity.

  At enrollment (single time point)

Study Arms (2)

Premature Ejaculation

Men aged 18-55 years meeting ISSM criteria for lifelong or acquired premature ejaculation. Lifelong PE is defined as ejaculation occurring within approximately 1 minute of vaginal penetration since first sexual experience. Acquired PE is defined as ejaculation within approximately 3 minutes of vaginal penetration. All participants must have an inability to delay ejaculation and report negative personal consequences. Participants must have normal erectile function (IIEF-15 ≥26), be in a stable heterosexual monogamous relationship for at least 6 months, and have a clinically indicated mpMRI scheduled.

Control Group

Healthy men aged 18-55 years without premature ejaculation or any other sexual dysfunction complaint. Participants must have good ejaculatory control, normal erectile function (IIEF-15 ≥26), and be in a stable heterosexual monogamous relationship for at least 6 months. Participants must have a clinically indicated mpMRI scheduled due to elevated PSA or hematospermia.

Eligibility Criteria

• Age: 18 Years - 55 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

* Any major psychiatric or somatic disorder * Hormonal disorders such as hypothyroidism or hyperthyroidism * Erectile dysfunction (IIEF-15 erectile function domain score \<26) * Age below 18 or above 55 years

You may qualify if:

• \- Male aged 18 to 55 years
• In a stable, heterosexual, monogamous relationship with the same female partner for at least 6 months
• Normal erectile function defined as IIEF-15 erectile function domain score ≥26
• Scheduled for clinically indicated multiparametric prostate MRI due to elevated PSA or hematospermia
• Not using any medication that may affect sexual function or psychological status (e.g., SSRIs, PDE5 inhibitors)

You may not qualify if:

• Any major psychiatric or somatic disorder
• Hormonal disorders such as hypothyroidism or hyperthyroidism
• Erectile dysfunction (IIEF-15 erectile function domain score \<26)
• Age below 18 or above 55 years

Sponsors & Collaborators

• Başakşehir Çam & Sakura City Hospital: lead

Study Sites (1)

Başakşehir Çam and Sakura City Hospital, Department of Urology

Istanbul, Istanbul, 34200, Turkey (Türkiye)

Location

Related Publications (2)

• Forbes CM, Flannigan R, Paduch DA. Perineal Ultrasound: a Review in the Context of Ejaculatory Dysfunction. Sex Med Rev. 2018 Jul;6(3):419-428. doi: 10.1016/j.sxmr.2017.12.005. Epub 2018 Feb 17.

  PMID: 29463441 BACKGROUND

• Serefoglu EC, McMahon CG, Waldinger MD, Althof SE, Shindel A, Adaikan G, Becher EF, Dean J, Giuliano F, Hellstrom WJ, Giraldi A, Glina S, Incrocci L, Jannini E, McCabe M, Parish S, Rowland D, Segraves RT, Sharlip I, Torres LO. An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the second international society for sexual medicine ad hoc committee for the definition of premature ejaculation. Sex Med. 2014 Jun;2(2):41-59. doi: 10.1002/sm2.27.

  PMID: 25356301 BACKGROUND

Related Links

• Related Info

MeSH Terms

Conditions

Premature Ejaculation

Condition Hierarchy (Ancestors)

Ejaculatory Dysfunction; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Sexual Dysfunction, Physiological; Male Urogenital Diseases; Sexual Dysfunctions, Psychological; Mental Disorders

Central Study Contacts

VEYSEL SEZGİN, MD

CONTACT

+905513895655; veyselsezgin1@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD VEYSEL SEZGİN

Study Record Dates

• First Submitted: May 22, 2026
• First Posted: May 29, 2026
• Study Start: May 10, 2026
• Primary Completion (Estimated): August 10, 2026
• Study Completion (Estimated): August 10, 2026
• Last Updated: June 3, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)