To Study and Explore the Predictive Effect of Insulin Resistance-related Indicators on In-stent Restenosis After Coronary Stent Implantation

NCT07614763 | Completed DMC

• 1 other identifier: KYLL-2025-11-064
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Based on previous studies on insulin resistance and cardiovascular diseases, we believe that the insulin resistance metabolic score also has certain predictive value for the prognosis of in-stent restenosis after coronary stent implantation. The main purpose of this study is to explore the predictive effect of the insulin resistance metabolic score on in-stent restenosis after coronary stent implantation and to discuss a reasonable control level.

Conditions

Coronary Artery Disease; In-stent Restenosis

Outcome Measures

Primary Outcomes (1)

• Incidence of in-stent restenosis greater than 50% and greater than 70% assessed by follow-up coronary angiography

  In-stent restenosis was defined as recurrent luminal diameter stenosis within the stented segment or within 5 mm proximal or distal to the stent edges, as determined by follow-up coronary angiography. Percent diameter stenosis was used to quantify the severity of restenosis. Participants will be classified according to whether they had in-stent restenosis greater than 50% and greater than 70%, and the outcome will be summarized as the number and percentage of participants in each category.

  During follow-up coronary angiography within 6-60 months after PCI

Interventions

Observational studies do not design intervention measures OTHER

Observational studies do not design intervention measures

Eligibility Criteria

• Age: 45 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We retrospectively collected the clinical data of patients with recurrent chest pain after PCI and requiring repeated angiography from January 2022 to November 2025, which were obtained from electronic medical records.

You may qualify if:

• Age ≥45 years
• Patients with a history of percutaneous coronary intervention (PCI) with stent implantation
• Patients who underwent repeat coronary angiography during follow-up
• Complete clinical data available, including echocardiography, 24-hour ambulatory electrocardiogram, NT-proBNP, liver and kidney function tests, and blood biochemical tests

You may not qualify if:

• Previous coronary artery bypass grafting
• Lesions treated only with balloon angioplasty without stent implantation
• Clinical manifestations of heart failure, structural cardiomyopathy, congenital heart disease, or significant valvular heart disease
• Severe hepatic or renal dysfunction, such as estimated glomerular filtration rate \<30 mL/min/1.73 m²
• Incomplete clinical or angiographic data

Sponsors & Collaborators

• Qilu Hospital of Shandong University: lead

Study Sites (1)

Qilu Hospital of Shandong University

Jinan, Shandong, 250012, China

Location

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 6, 2026
• First Posted: May 29, 2026
• Study Start: January 1, 2022
• Primary Completion: November 1, 2025
• Study Completion: November 1, 2025
• Last Updated: May 29, 2026

Record last verified: 2026-01

Locations

CN (1)