Phase Resolved Functional Lung MRI and Oscillometry for the Observation of Healthy Lung Function

NCT07614685 | Not Yet Recruiting FDA Device

• 1 other identifier: STUDY00011843
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine the relationship of airways resistance measured by oscillometry with ventilation defects measured by Phase Resolved Functional Lung (PREFUL) MRI in healthy human subjects.

Conditions

Breathing; Lung Function Decreased; MRI Imaging; Healthy

Outcome Measures

Primary Outcomes (2)

• Oscillometer

  The oscillometer will collect an airway impedance measurement which is made up of multiple variables.

  Single measurement, approximately 1 day

• Phase Resolved Functional Lung (PREFUL) MRI

  PREFUL MRI will acquire images of the lungs and a measurement called the ventilatory defect percentage (or VDP) will be calculated.

  Single measurement, approximately 1 day

Study Arms (1)

All participants

Device: Airway Oscillometer; Diagnostic Test: Phase Resolved Functional Lung MRI

Interventions

Airway Oscillometer DEVICE

The termoflo c-100 Airwave Oscillometer System is intended to measure respiratory system impedance using the Forced Oscillation Technique (FOT).

All participants

Phase Resolved Functional Lung MRI DIAGNOSTIC_TEST

The Phase Resolved Functional Lung (PREFUL) MRI technique acquires images of the lung so that measures of ventilatory defect percentage can be calculated.

All participants

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Up to twenty (20) healthy human subjects will be recruited from the outpatient clinics at the University of Rochester Medical Center and the Mary Parkes Asthma Center.

You may qualify if:

• Age 18 years or older
• Ability to provide consent
• Willingness to perform MRI and breathing test
• Must be able to speak and understand English

You may not qualify if:

• Pregnant
• Unable or willing to provide consent or perform the required maneuvers for testing.

Sponsors & Collaborators

• University of Rochester: lead

Study Sites (1)

University of Rochester Medical Center

Rochester, New York, 14642, United States

Location

MeSH Terms

Conditions

Respiratory Aspiration; Respiratory Insufficiency

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Patrick Donohue, MD

CONTACT

585-210-9301; patrick_donohue@urmc.rochester.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: May 20, 2026
• First Posted: May 29, 2026
• Study Start (Estimated): July 1, 2026
• Primary Completion (Estimated): July 1, 2027
• Study Completion (Estimated): January 1, 2028
• Last Updated: May 29, 2026

Record last verified: 2026-05

Locations

US (1)