A Study of Magnetic Resonance Imaging of the Pancreas for Cancer Screening
Pilot Study of a Dedicated MR of the Pancreas: Improving Screening for Patients at High Risk for Pancreas Cancer
1 other identifier
observational
79
1 country
7
Brief Summary
The purpose of this study is to develop a dedicated MRI scan of the pancreas (MRP) to better detect pancreatic cancer in people who are at a high risk for pancreatic cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2026
7 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 20, 2026
CompletedFirst Submitted
Initial submission to the registry
May 21, 2026
CompletedFirst Posted
Study publicly available on registry
May 28, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 20, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
May 20, 2028
May 28, 2026
May 1, 2026
2 years
May 21, 2026
May 21, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Compare image quality of novel high-resolution magnetic resonance pancreas (MRP) to conventional MRCP
Develop and pilot a focused high-resolution magnetic resonance pancreas (MRP) exam to help facilitate early pancreatic cancer detection in high-risk individuals. Image quality for T1, T2, and DWI sequences performed on the novel MRP exam will be compared to conventional MRCP performed in the same participants.
Up to 3 years
Study Arms (1)
Participants at high risk for pancreas ductal adenocarcinoma
Participants will be high-risk individuals enrolled in the Memorial Sloan Kettering Pancreatic Tumor Registry
Interventions
Participants will undergo a single MRI of the abdomen without contrast
EUS will be scheduled the same day or within 2 weeks prior to MRP
Eligibility Criteria
Investigators will conduct this pilot study in high-risk individuals enrolled in the Memorial Sloan Kettering Pancreatic Tumor Registry
You may qualify if:
- Two first-degree relatives with pancreas cancer, one being a first-degree relative to the individual
- Pathogenic mutation in APC, BRCA1, MLH1, MSH2, MSH6, PMS2, EPCAM, PALB2, or TP53 and a first/second-degree relative with pancreas cancer
- Pathogenic mutation in CDKN2A/p16, STK11, PRSS1, SPINK1/PST1, CTRC, CPA1, ATM, or BRCA2
- Meets surveillance age eligibility, which is typically age 50, or 10 years earlier than the youngest relative with pancreas cancer. For individuals with certain gene mutations, this can be earlier. All participants must be aged 21+
- For this pilot MRP study, we will additionally apply the following Criteria:
- Consents to follow-up contact
- US residents
- Completed MRI with MRCP with no actionable findings related to the pancreas (e.g. a pancreatic mass)
- No metallic artifacts covering the pancreas on prior MRCP
- Scheduled for endoscopic ultrasound
- No new contraindications for MRI (e.g. new MR unsafe device)
- No history of claustrophobia or use of anxiolytic on prior MRI
- No history of abdominal surgery that may affect interpretation of either EUS or MR
- No medical conditions that confers increased and/or unacceptable risk for anesthesia
- We will recruit surveillance participants who had at least one prior MRCP in the last 3 years. They must also undergo a same-day EUS procedure as part of their surveillance. Nearly all active cohort participants have had at least one recent MRCP and, on average, our Registry gastroenterologist Dr. Rolston performs EUS in \~260 surveillance participants per year. Accordingly, it is highly feasible to recruit more than 79 participants in the grant period, and recruitment is constrained by budget.
- +5 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (7)
Memorial Sloan Kettering Basking Ridge (Consent Only)
Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Monmouth (Consent only)
Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Bergen (Consent Only)
Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Suffolk-Commack (Consent only)
Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Consent only)
Harrison, New York, 10604, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activites)
New York, New York, 10065, United States
Memorial Sloan Kettering Nassau (Consent Only)
Uniondale, New York, 11553, United States
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Richard Kinh Gian Do, MD, PhD
Memorial Sloan Kettering Cancer Center
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 21, 2026
First Posted
May 28, 2026
Study Start
May 20, 2026
Primary Completion (Estimated)
May 20, 2028
Study Completion (Estimated)
May 20, 2028
Last Updated
May 28, 2026
Record last verified: 2026-05
Data Sharing
- IPD Sharing
- Will share
• Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made following one year after publication and for up to 36 months later. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.