Analysis of Chlordecone Tissue Concentrations in Patients Treated for Thyroid Surgery at Guadeloupe University Hospital

NCT07611994 | Not Yet Recruiting

• 1 other identifier: PAP_RIPH2_2025/08
• Study Type: interventional
• Target: 69
• Locations: 1 country
• Sites: 1

Brief Summary

Chlordecone, an organochlorine pesticide used in the French Caribbean for several decades, is recognized as an endocrine disruptor. Accumulation in thyroid tissue may be modeled using several factors, including blood chlordecone levels, environmental exposure associated with place of residence, and dietary habits.

Conditions

Thyroid and Parathyroid Surgery

Keywords

chlordecone; thyroid nodes; thyroid disruptor

Outcome Measures

Primary Outcomes (2)

• chlordecone concentration in the adipose tissue adjacent to the thyroid

  Chlordecone concentration measured in adipose tissue adjacent to the thyroid collected during thyroid surgery.

  During surgery

• Chlordecone concentration in blood

  Chlordecone concentration measured in blood samples collected one day before surgery.

  1 day before surgery

Secondary Outcomes (3)

• Occupational exposure category

  At enrollment

• Residential environmental exposure assessment

  At enrollment

• Dietary exposure assessment

  At enrollment

Study Arms (1)

Participants undergoing thyroid surgery

OTHER

Participants undergoing thyroid surgery with prospective collection of blood, thyroid tissue, and adjacent adipose tissue samples for chlordecone concentration assessment and evaluation of exposure-related factors.

Other: Blood and thyroid tissue collection

Interventions

Blood and thyroid tissue collection OTHER

Collection of blood, thyroid tissue, and adjacent adipose tissue samples during routine thyroid surgery for measurement of chlordecone concentration and assessment of exposure-related factors.

Participants undergoing thyroid surgery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• adult patients hospitalized at the Guadeloupe University Hospital for surgical treatment of thyroid pathology
• person affiliated to or beneficiaries of a social security system
• person with free, informed, and written consent signed by the participant and the investigator

You may not qualify if:

• patients subject to a judicial safeguard measure,
• patient under 18 years old
• patient without signed consent

Sponsors & Collaborators

• Centre Hospitalier Universitaire de la Guadeloupe: lead
• Institut Pasteur de Guadeloupe: collaborator

Study Sites (1)

CHU de la Guadeloupe

Les Abymes, 97159, Guadeloupe

Location

MeSH Terms

Conditions

Thyroid Diseases

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• suzy Duflo, MD PhD

  CHU de la Guadeloupe

  PRINCIPAL INVESTIGATOR

Central Study Contacts

mélanie petapermal, Master degree

CONTACT

+590590934667; melanie.petapermal@chu-guadeloupe.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Observational, analytical, single-center, cross-sectional study with prospective data collection.

Study Record Dates

• First Submitted: May 21, 2026
• First Posted: May 28, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): November 1, 2027
• Study Completion (Estimated): November 1, 2027
• Last Updated: June 1, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

GU (1)