Inter-Individual Variability in Early Diet-Induced Thermogenesis After a Standardized Meal

NCT07610759 | Not Yet Recruiting

• 1 other identifier: 0012144-1
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to characterize how individuals differ in their metabolic response to food intake, specifically focusing on early diet-induced thermogenesis (DIT). DIT refers to the increase in energy expenditure that occurs after eating and reflects the body's metabolic response to processing nutrients. Healthy adult participants will complete a single laboratory visit under standardized conditions. Resting metabolic rate will first be measured, followed by consumption of a standardized liquid meal (550 kcal). Energy expenditure will then be continuously monitored for 3 hours using indirect calorimetry. The primary objective is to quantify inter-individual variability in early postprandial thermogenesis. Rather than estimating total daily energy expenditure, this study focuses on the early metabolic response following meal ingestion. Findings will improve understanding of differences in metabolic efficiency between individuals and support future research in metabolism and personalized nutrition.

Conditions

Diet-induced Thermogenesis

Keywords

Diet-induced thermogenesis; Postprandial metabolism; Energy expenditure; Metabolic variability; Indirect calorimetry; Standardized meal

Outcome Measures

Primary Outcomes (1)

• Early Diet-Induced Thermogenesis Area Under the Curve

  Area under the curve for diet-induced thermogenesis over 180 minutes after consumption of the standardized liquid meal. DIT will be calculated as postprandial energy expenditure minus baseline resting energy expenditure and expressed as kcal/180 min.

  From meal completion to 180 minutes post-meal

Secondary Outcomes (5)

• Mean Diet-Induced Thermogenesis

  From meal completion to 180 minutes post-meal

• Peak Diet-Induced Thermogenesis

  From meal completion to 180 minutes post-meal

• Time to Peak Diet-Induced Thermogenesis

  Time from completion of the standardized liquid meal to the maximum observed increase in energy expenditure, expressed in minutes.

• Percent Increase in Energy Expenditure Above Baseline

  From meal completion to 180 minutes post-meal

• Fat-Free Mass-Normalized Diet-Induced Thermogenesis

  From meal completion to 180 minutes post-meal

Study Arms (1)

Healthy Adult Participants

EXPERIMENTAL

Healthy adults (≥18 years) participating in a single laboratory visit. All participants undergo resting metabolic rate assessment, consume a standardized liquid meal (550 kcal), and complete continuous postprandial energy expenditure measurement using indirect calorimetry under controlled conditions.

Other: Standardized Liquid Meal

Interventions

Standardized Liquid Meal OTHER

Consumption of a standardized liquid meal (\~550 kcal) under controlled laboratory conditions, followed by continuous measurement of energy expenditure using indirect calorimetry for assessment of postprandial thermogenesis. The procedure is used for measurement purposes only and is not intended as a therapeutic intervention.

Also known as: Ensure®

Healthy Adult Participants

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged ≥18 years
• Stable body weight (±2 kg over the previous 3 months)
• Generally healthy individuals
• Ability to comply with study procedures, including fasting and remaining at rest - during measurements

You may not qualify if:

• Use of medications known to affect metabolism (e.g., GLP-1 receptor agonists, systemic corticosteroids, uncontrolled thyroid disease)
• Insulin-treated diabetes
• Pregnancy or lactation
• Acute illness at the time of testing
• Inability to comply with pre-test requirements (e.g., fasting, avoiding caffeine, alcohol, or physical activity)

Sponsors & Collaborators

• Tel Aviv University: lead

Study Sites (1)

Sylvan Adams Sport Science Institute

Tel Aviv, 6428607, Israel

Location

Central Study Contacts

Yftach Prof. Gepner

CONTACT

0506828501; gepner@tauex.tau.ac.il

Lien Bruck

CONTACT

0587487431; lienbruck@tauex.tau.ac.il

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator - Professor

Model Details: All participants undergo a single standardized protocol including baseline resting metabolic rate assessment, consumption of a standardized liquid meal, and continuous postprandial energy expenditure measurement under controlled laboratory conditions.

Study Record Dates

• First Submitted: May 13, 2026
• First Posted: May 28, 2026
• Study Start: June 1, 2026
• Primary Completion (Estimated): June 1, 2027
• Study Completion (Estimated): June 1, 2027
• Last Updated: May 28, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

IL (1)